{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:59:33Z","timestamp":1788872373932,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T00:00:00Z","timestamp":1355702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["CA131029"],"award-info":[{"award-number":["CA131029"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["CA126857"],"award-info":[{"award-number":["CA126857"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["UL1RR025755"],"award-info":[{"award-number":["UL1RR025755"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["CA16058"],"award-info":[{"award-number":["CA16058"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"American Cancer Society Postdoctoral Fellowship","award":["PF-11-007-01-CPPB"],"award-info":[{"award-number":["PF-11-007-01-CPPB"]}]},{"name":"National Cancer Institute Research Supplement to Promote Diversity in Health-Related Research","award":["CA126857"],"award-info":[{"award-number":["CA126857"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A cancer diagnosis provokes significant levels of emotional distress, with intrusive thoughts being the most common manifestation among breast cancer survivors. Cancer\u2010related intrusive thoughts can take the form of emotional memories, flashbacks, nightmares, and intrusive images. Emotional arousal after a severe life stressor prolongs adrenergic activation, which in turn may increase risk for post\u2010traumatic symptomatology. However, antihypertensive beta\u2010blockers block adrenergic activation and are known to reduce traumatic memories and related psychological distress. Thus, the current study examined the association between beta\u2010blocker use and the severity of cancer\u2010related intrusive thoughts and related symptoms following a cancer diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The 174 breast and 36 female colorectal cancer patients who had recently undergone diagnostic screening or biopsy included 39 beta\u2010blocker users and 171 non\u2010users. Prior to any cancer treatment including surgery, participants completed questionnaires that included the Impact of Events Scale and the Center for Epidemiological Studies Depression Scale. Analyses controlled for age, education, cancer stage, cancer type, days since diagnosis, marital status, depression, and comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Although the high rates of cancer\u2010related distress in this sample were similar to those of other studies with recently diagnosed patients, beta\u2010blocker users endorsed 32% fewer cancer\u2010related intrusive thoughts than non\u2010users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Recently diagnosed cancer patients using beta\u2010blockers reported less cancer\u2010related psychological distress. These results suggest that beta\u2010blocker use may benefit cancer patients' psychological adjustment following diagnosis, and provide a promising direction for future investigations on the pharmacological benefits of beta\u2010blockers for cancer\u2010related distress. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.3233","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T11:48:58Z","timestamp":1355831338000},"page":"1889-1894","source":"Crossref","is-referenced-by-count":29,"title":["Beta\u2010blockers may reduce intrusive thoughts in newly diagnosed cancer patients"],"prefix":"10.1002","volume":"22","author":[{"given":"Monica E.","family":"Lindgren","sequence":"first","affiliation":[{"name":"Institute for Behavioral Medicine Research, College of Medicine The Ohio State University  Columbus OH USA"},{"name":"Department of Psychology The Ohio State University  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Fagundes","sequence":"additional","affiliation":[{"name":"Institute for Behavioral Medicine Research, College of Medicine The Ohio State University  Columbus OH 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