{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:55:04Z","timestamp":1791428104388,"version":"4.3.3"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,2,18]],"date-time":"2013-02-18T00:00:00Z","timestamp":1361145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objectives of this study are to determine (i) what daughters, ages 18\u201324\u2009years, of <jats:italic>BRCA1\/2<\/jats:italic> mutation carriers understand about their 50% chance of carrying a <jats:italic>BRCA1\/2<\/jats:italic> mutation and about risk reduction or management options for mutation carriers, (ii) the extent and nature of daughters' cancer\u2010related distress, and (iii) the effects of knowing mother's mutation status on daughters' future plans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 40 daughters, currently aged 18\u201324\u2009years, of mothers who tested positive for a mutation in <jats:italic>BRCA1\/2<\/jats:italic> were invited by mail to participate (with contact information supplied by their mothers). Daughters participated in a qualitative telephone interview about the impact of learning their mother's mutation status on their understanding of their own cancer risks and their cancer\u2010related distress, and their knowledge of screening strategies, risk\u2010reducing surgery, current health status, and future plans. Participants also completed study\u2010specific demographic and family history questionnaires, the Brief Symptom Inventory\u201018, Impact of Event Scale (with hereditary predisposition to breast\/ovarian cancer as the event), and the Breast Cancer Genetic Counseling Knowledge Questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Daughters' genetic knowledge is suboptimal; gaps and misconceptions were common. Over 1\/3 of the daughters reported high cancer\u2010related distress, despite normal levels of general distress. Disclosed genetic information raised future concerns, especially regarding childbearing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Targeted professional attention to this high\u2010risk cohort of young women is critical to inform the next generation of daughters of <jats:italic>BRCA1\/2<\/jats:italic> mutation carriers and encourage recommended screening by age 25\u2009years. Improved uptake of screening and risk reduction options could improve survival, and psychoeducation could reduce cancer\u2010related distress. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.3257","type":"journal-article","created":{"date-parts":[[2013,2,18]],"date-time":"2013-02-18T22:52:14Z","timestamp":1361227934000},"page":"2024-2031","source":"Crossref","is-referenced-by-count":52,"title":["Young adult daughters of <i>BRCA1\/2<\/i> positive mothers: What do they know about hereditary cancer and how much do they worry?"],"prefix":"10.1002","volume":"22","author":[{"given":"Andrea F.","family":"Patenaude","sequence":"first","affiliation":[{"name":"Dana\u2013Farber Cancer Institute  Boston MA USA"},{"name":"Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Tung","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Hospital  Boston MA USA"},{"name":"Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula D.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston MA USA"},{"name":"Fox Chase Cancer Center  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif W.","family":"Ellisen","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston MA USA"},{"name":"Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Hewitt","sequence":"additional","affiliation":[{"name":"Dana\u2013Farber Cancer Institute  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Dana\u2013Farber Cancer Institute  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth P.","family":"Tercyak","sequence":"additional","affiliation":[{"name":"Georgetown University Medical Center  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Aldridge","sequence":"additional","affiliation":[{"name":"Dana\u2013Farber Cancer Institute  Boston MA USA"},{"name":"Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy E.","family":"Garber","sequence":"additional","affiliation":[{"name":"Dana\u2013Farber Cancer Institute  Boston MA USA"},{"name":"Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,18]]},"reference":[{"issue":"4","key":"e_1_2_12_2_1","first-page":"293","article-title":"BRCA1\/2 predictive testing and gender: uptake, motivation and psychological characteristics","volume":"20","author":"Denayer L","year":"2009","journal-title":"Genet Couns"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705153362001"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91578-4"},{"key":"e_1_2_12_5_1","first-page":"265","article-title":"Breast and ovarian cancer incidence in BRCA1\/2 mutation carriers","volume":"56","author":"Easton DF","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.1066"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/301749"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/375033"},{"key":"e_1_2_12_9_1","unstructured":"National Comprehensive Cancer Network.Genetic\/familial high\u2010risk assessment: breast and ovarian cancer NCCN clinical practice guidelines in oncology v.1 2012. 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