{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T06:28:03Z","timestamp":1764570483129},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,4,14]],"date-time":"2013-04-14T00:00:00Z","timestamp":1365897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Paraneoplastic syndromes are of interest to psycho\u2010oncologists because they may be misdiagnosed initially as primary psychiatric disorders and can have profound neuropsychiatric and psychosocial sequelae. Paraneoplastic cerebellar degeneration (PCD) is a paraneoplastic syndrome which destroys Purkinje cells of the cerebellum and causes trunk and limb ataxia, dysarthria, diplopia, and vertigo, which often precede the diagnosis of cancer. Anti\u2010Yo PCD is a devastating syndrome that significantly worsens prognosis in terms of functional ability and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We present the case of a woman with progressive cerebellar deficits, which were misdiagnosed for several months before breast cancer and anti\u2010Yo antibodies were discovered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PCD may be misdiagnosed as a primary psychiatric disorder. Results of neuropsychological assessment in this case found subtle attentional dysfunction but relatively preserved cognitive functioning in other domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The literature relating to PCD and psychiatric manifestations of cerebellar disease are reviewed. The limitations of our current understanding of non\u2010motor cerebellar function are highlighted, asserting the need for further study in this area. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.3270","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T03:39:32Z","timestamp":1365997172000},"page":"2152-2155","source":"Crossref","is-referenced-by-count":16,"title":["Anti\u2010Yo mediated paraneoplastic cerebellar degeneration in the context of breast cancer: a case report and literature review"],"prefix":"10.1002","volume":"22","author":[{"given":"Richard Garrett","family":"Key","sequence":"first","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center Psychiatry and Behavioral Sciences  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Root","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center Department of Psychiatry and Behavioral Sciences  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.034447"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.10.1931"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg133"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-010-0066-9"},{"issue":"2","key":"e_1_2_5_6_1","first-page":"144","article-title":"Anti\u2010Yo antibody associated paraneoplastic cerebellar degeneration with gastric adenocarcinoma in a male patient: a case report","volume":"46","author":"Goto A","year":"2006","journal-title":"Rinsho Shinkeigaku"},{"issue":"3","key":"e_1_2_5_7_1","first-page":"18","article-title":"Anti\u2010Yo antibody\u2010mediated paraneoplastic cerebellar degeneration in a man with esophageal adenocarcinoma","volume":"5","author":"Xia K","year":"2003","journal-title":"MedGenMed"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.12.019"},{"issue":"7","key":"e_1_2_5_9_1","first-page":"243","article-title":"Paraneoplastic cerebellar degeneration preceding the diagnosis of Hodgkin's lymphoma","volume":"64","author":"Ypma PF","year":"2006","journal-title":"Neth J Med"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199906)45:6<805::AID-ANA18>3.0.CO;2-G"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000113749.77217.01"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1127"},{"issue":"4","key":"e_1_2_5_13_1","first-page":"309","article-title":"Pathogenesis of paraneoplastic neurological syndromes","volume":"62","author":"Tanaka K","year":"2010","journal-title":"Brain Nerve"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.2008.00604.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5407-9"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-5005-z"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5859-y"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0882-0"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1774-9987.2004.00198.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-006-9198-x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(98)01211-X"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpon.3270","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpon.3270","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.3270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T13:03:44Z","timestamp":1697461424000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.3270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,14]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1002\/pon.3270"],"URL":"https:\/\/doi.org\/10.1002\/pon.3270","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,14]]}}}