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Average age was 46.7\u00a0years (SD\u2009=\u200911.9), 59% were male, and the majority were identified as Caucasian (93%). Principal components analysis with the CTXD identified 22 items that loaded onto six factors explaining 69% of the variance: uncertainty, health burden, identity, medical demands, finances, and family strain. Internal consistency reliability for the 22 items was 0.91. The receiver operating characteristic area under the curve was 0.85 (95% CI [0.79, 0.91]), with a cut point of 1.1 resulting in a sensitivity rate of 0.91 and a specificity rate of 0.58. Convergent validity and divergent validity were confirmed with large correlations of the CTXD total score with the CESD, Profile of Mood States, and SF\u201036 mental health; and a smaller correlation with the SF\u201036 physical function (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.30).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The CTXD is a reliable and valid measure of distress for HCT recipients and captures nearly all cases of depression on the CESD in addition to detecting distress in those who are not depressed. It has potential value as both a research and clinical screening measure for distress. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.3861","type":"journal-article","created":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T05:15:08Z","timestamp":1435641308000},"page":"529-535","source":"Crossref","is-referenced-by-count":38,"title":["Psychometric properties of the <scp>Cancer and Treatment Distress<\/scp> (CTXD) measure in hematopoietic cell transplantation patients"],"prefix":"10.1002","volume":"25","author":[{"given":"Karen L.","family":"Syrjala","sequence":"first","affiliation":[{"name":"Fred Hutchinson Cancer Research Center  Seattle WA USA"},{"name":"University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean C.","family":"Yi","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby 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