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Given that there has been little research on the psychological impact of such malignancies with acute onset, we assessed the prevalence and correlates of depression and hopelessness in patients with AL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred forty\u2010one participants were recruited within 1\u00a0month of diagnosis or relapse and completed the Beck Depression Inventory\u2010II (BDI\u2010II), Beck Hopelessness Scale (BHS), Memorial Symptom Assessment Scale, and other psychosocial measures. Multivariate regression analyses identified correlates of depression and hopelessness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>17.8% reported clinically significant depressive symptoms (BDI\u2010II\u2009\u2265\u200915), 40.4% of which were in the moderate\u2010severe range (BDI\u2010II\u2009\u2265\u200920). 8.5% reported significant symptoms of hopelessness (BHS\u2009\u2265\u20098). Depression was associated with greater physical symptom burden (adjusted<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200948.4%), while hopelessness was associated with older age and lower self\u2010esteem (adjusted<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200945.4%). Both were associated with poorer spiritual well\u2010being.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinically significant depressive symptoms were common early in the course of AL and related to physical symptom burden. Hopelessness was less common and associated with older age and lower self\u2010esteem. The results suggest that whereas depression in AL may be related to disease burden, the preservation of hope may be linked to individual resilience, life stage, and realistic prognosis.Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.3940","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T10:14:46Z","timestamp":1442571286000},"page":"979-989","source":"Crossref","is-referenced-by-count":58,"title":["Depression and hopelessness in patients with acute leukemia: the psychological impact of an acute and life\u2010threatening disorder"],"prefix":"10.1002","volume":"25","author":[{"given":"Galina","family":"Gheihman","sequence":"first","affiliation":[{"name":"Faculty of Arts &amp; Science University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Supportive Care, Princess Margaret Cancer Centre University Health Network Toronto Canada"},{"name":"Campbell Family Cancer Research Institute, Ontario Cancer Institute University Health Network Toronto Canada"},{"name":"Department of Medicine University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Deckert","sequence":"additional","affiliation":[{"name":"Department of Supportive Care, Princess Margaret Cancer Centre University Health Network Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Supportive Care, Princess Margaret Cancer Centre University Health Network Toronto Canada"},{"name":"Department of Psychiatry University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Mischitelle","sequence":"additional","affiliation":[{"name":"Department of Supportive Care, Princess Margaret Cancer Centre University Health Network Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Rydall","sequence":"additional","affiliation":[{"name":"Department of Supportive Care, Princess Margaret Cancer Centre University Health Network Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Schimmer","sequence":"additional","affiliation":[{"name":"Campbell Family Cancer Research Institute, Ontario Cancer Institute University Health Network Toronto Canada"},{"name":"Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre University Health Network Toronto Canada"},{"name":"Department of Medical Biophysics University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Gagliese","sequence":"additional","affiliation":[{"name":"Department of Supportive Care, Princess Margaret Cancer Centre University Health Network Toronto Canada"},{"name":"Campbell Family Cancer Research Institute, Ontario Cancer Institute University Health Network Toronto Canada"},{"name":"Department of Psychiatry University of Toronto Toronto Canada"},{"name":"School of Kinesiology and Health Science York University Toronto Canada"},{"name":"Department of Anesthesia University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Supportive Care, Princess Margaret Cancer Centre University Health Network Toronto Canada"},{"name":"Department of Psychiatry University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Rodin","sequence":"additional","affiliation":[{"name":"Department of Supportive Care, Princess Margaret Cancer Centre University Health Network Toronto Canada"},{"name":"Campbell Family Cancer Research Institute, Ontario Cancer Institute University Health Network Toronto Canada"},{"name":"Department of Psychiatry University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Leukemia and Lymphoma Society of Canada.Leukemia: facts and statistics.2013. 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