{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:48:48Z","timestamp":1792540128975,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA165001"],"award-info":[{"award-number":["R01 CA165001"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA16520"],"award-info":[{"award-number":["P30 CA16520"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Continuing to smoke after a cancer diagnosis can adversely influence the prognosis for patients with cancer. However, remarkably few studies have carefully examined the use of first\u2010line FDA\u2010approved medications for nicotine dependence in patients with cancer. This study evaluated the feasibility, safety, and effect on cessation of varenicline for smoking cessation in patients with cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 132 treatment\u2010seeking smokers who received 12 weeks of open\u2010label varenicline and five brief behavioral counseling sessions were used to evaluate the feasibility, safety, and impact on cessation of varenicline. The effects of abstinence on cognitive function and affect were also explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 459 patients screened, 306 were eligible for the study (66.7%) and 132 entered treatment (43.1%). Retention was 84.1% over 12 weeks. The rate of biochemically verified abstinence at week 12 was 40.2%. Expected side effects were reported (e.g. sleep problems, nausea), but there were no reports of elevated depressed mood, suicidal thoughts, or cardiovascular events. Abstinence was associated with improved cognitive function and reduced negative affect over time (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although many patients with cancer who smoke did not enroll in treatment, the side effect profile of varenicline and its effect on short\u2010term cessation converge with what is seen in the general population. Further, as with the general population, abstinence while taking varenicline may lead to improved cognitive function and reduced negative affect. The present data support the use of varenicline to help patients with cancer to quit smoking.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.4166","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T01:56:34Z","timestamp":1464141394000},"page":"1526-1534","source":"Crossref","is-referenced-by-count":21,"title":["The use of varenicline to treat nicotine dependence among patients with cancer"],"prefix":"10.1002","volume":"26","author":[{"given":"Sarah","family":"Price","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Hitsman","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine  Chicago IL USA"},{"name":"Robert H. Lurie Comprehensive Cancer Center Northwestern University Feinberg School of Medicine  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Veluz\u2010Wilkins","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Blazekovic","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarah R.","family":"Brubaker","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Leone","sequence":"additional","affiliation":[{"name":"Pulmonary, Allergy, and Critical Care Division University of Pennsylvania Presbyterian Medical Center  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Hole","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Paul","family":"Wileyto","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Langer","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania, Perelman Center for Advanced Medicine  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Kalhan","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine  Chicago IL USA"},{"name":"Department of Medicine Northwestern University Feinberg School of Medicine  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Patel","sequence":"additional","affiliation":[{"name":"Robert H. Lurie Comprehensive Cancer Center Northwestern University Feinberg School of Medicine  Chicago IL USA"},{"name":"Department of Medicine Northwestern University Feinberg School of Medicine  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Schnoll","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"US Department of Health and Human Services.The health consequences of smoking\u201450 years of progress: a report of the surgeon general. Atlanta GA: US Department of Health and Human Services Centers for Disease Control and Prevention National Center for Chronic Disease Prevention and Health Promotion Office on Smoking and Health 2014."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-016-0515-x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntv177"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-015-0477-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-1182"},{"key":"e_1_2_6_7_1","volume-title":"SEER Cancer Statistics Review, 1975\u20102012","author":"Howlader N","year":"2015"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.1.56"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.090647"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.08.028"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.05.033"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.869008"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-6-201309170-00005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318215a4dc"},{"key":"e_1_2_6_15_1","unstructured":"FioreMC Ja\u00e9nCR BakerTB et al.Treating tobacco use and dependence: 2008 update. Clinical Practice Guideline. Rockville MD US Public Health Service 2008."},{"issue":"20","key":"e_1_2_6_16_1","first-page":"22","article-title":"The Mini\u2010International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM\u2010IV and ICD\u201010","volume":"59","author":"Sheehan DV","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.10111704"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.8313"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70294-2"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1991.tb01879.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.54.6.1063"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2008.07.012"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntn031"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1037\/0893-164X.12.2.101"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-6-200403160-00009"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-3-201002020-00005"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntq215"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9507-8"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079907X182185"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntt066"},{"issue":"4","key":"e_1_2_6_31_1","first-page":"xliv","article-title":"Clinical Practice Guidelines in Oncology: Smoking Cessation, Version I. 2015","volume":"13","author":"NCCN","year":"2015","journal-title":"J Natl Compr Canc Netw"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntr333"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpon.4166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpon.4166","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.4166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T03:24:46Z","timestamp":1696044286000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.4166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,24]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/pon.4166"],"URL":"https:\/\/doi.org\/10.1002\/pon.4166","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,24]]}}}