{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:07:22Z","timestamp":1792678042695,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T00:00:00Z","timestamp":1466380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In childhood acute lymphoblastic leukemia (ALL), radiotherapy for CNS prophylaxis is not used in frontline therapy anymore. Standard treatment for ALL nowadays consists of polychemotherapy. Therefore, assessment of potential chemotherapy\u2010induced cognitive side effects becomes important. Although neurotoxicity was demonstrated in cross\u2010sectional studies, longitudinal studies remain scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We evaluated intellectual development of 94 pediatric ALL patients between 1990 and 1997, diagnosed before the age of 12\u00a0years, treated according to the European Organisation for Research and Treatment of Cancer Children's Leukemia Group 58881 protocol. Three assessments of the Wechsler Intelligence Scale for Children Revised were performed since diagnosis, according to age. Using repeated measures regression analysis, we investigated the effect of gender (low versus increased) risk group, parents' education, age at diagnosis, intelligence quotient (IQ) subscale (verbal (VIQ) versus performance (PIQ) intelligence), and test session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PIQ scores were lower than VIQ at baseline (\u22125.3 points on average, <jats:italic>p<\/jats:italic>\u2009=\u20090.0032), yet PIQ increased more strongly (PIQ: +3.9 points per test session; VIQ: +0.8, <jats:italic>p<\/jats:italic>\u2009=\u20090.0079), so this baseline difference disappeared (<jats:italic>p<\/jats:italic>\u2009=\u20090.0079). There were no clear effects of gender (girls: +0.6 points; <jats:italic>p<\/jats:italic>\u2009=\u20090.78) or risk group (low risk: +1.5 points; <jats:italic>p<\/jats:italic>\u2009=\u20090.49), but IQ scores were higher when one parent had followed higher education (+9.5 points, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Finally, diagnosis at younger age predicted lower IQ scores (\u22121.3 points per year, <jats:italic>p<\/jats:italic>\u2009=\u20090.0009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given that IQ scores did not decline, our findings demonstrate a stable pattern. However, the lower PIQ scores at baseline may indicate that performance functioning is vulnerable to acute neurotoxicity. Also, lower scores for younger patients highlight the stronger impact of the disease and\/or treatment at younger age.Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.4186","type":"journal-article","created":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T02:36:49Z","timestamp":1464748609000},"page":"508-514","source":"Crossref","is-referenced-by-count":26,"title":["Intellectual development of childhood ALL patients: a multicenter longitudinal study"],"prefix":"10.1002","volume":"26","author":[{"given":"Charlotte","family":"Sleurs","sequence":"first","affiliation":[{"name":"University Hospitals Leuven Department of Pediatric Hematology and Oncology  Leuven Belgium"},{"name":"KU Leuven Department of Development and Regeneration  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Lemiere","sequence":"additional","affiliation":[{"name":"University Hospitals Leuven Department of Pediatric Hematology and Oncology  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trui","family":"Vercruysse","sequence":"additional","affiliation":[{"name":"University Hospitals Leuven Department of Pediatric Hematology and Oncology  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Nolf","sequence":"additional","affiliation":[{"name":"Ghent University Hospital Department of Pediatric Hematology and Oncology  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Van Calster","sequence":"additional","affiliation":[{"name":"KU Leuven Department of Development and Regeneration  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Deprez","sequence":"additional","affiliation":[{"name":"University Hospitals Leuven Department of Radiology  Leuven Belgium"},{"name":"KU Leuven Department of Imaging and Pathology  Leuven 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