{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:30:17Z","timestamp":1788348617471,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007316","name":"Division of Cancer Prevention, National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA132803"],"award-info":[{"award-number":["R01 CA132803"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R25 CA090314"],"award-info":[{"award-number":["R25 CA090314"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The adverse sexual effects of androgen deprivation therapy (ADT) on men with prostate cancer have been well described. Less well known is the relative degree of sexual dysfunction and bother associated with ADT compared to other primary treatment modalities such as radical prostatectomy. We sought to describe the trajectory and relative magnitude of changes in sexual function and bother in men on ADT and to examine demographic and clinical predictors of ADT's adverse sexual effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prostate cancer patients treated with ADT (n\u00a0=\u00a060) completed assessments of sexual function and sexual bother 3 times during a 1\u2010year period after the initiation of ADT. Prostate cancer patients treated with radical prostatectomy only and not receiving ADT (n\u00a0=\u00a085) and men with no history of cancer (n\u00a0=\u00a086) matched on age and education completed assessments at similar intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Androgen deprivation therapy recipients reported worsening sexual function and increasing bother over time compared to controls. Effect sizes for the differences in sexual function were large to very large, and for bother were small to very large. Age younger than 83\u00a0years predicted relatively poorer sexual function, and age younger than 78\u00a0years predicted greater sexual bother at 12\u00a0months in men on ADT compared to men not on ADT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most men on ADT for prostate cancer will never return to baseline levels of sexual function. Interventions focused on sexual bother over function and designed to help couples build and maintain satisfying relationship intimacy are likely to more positively affect men's psychological well\u2010being while on ADT than medical or sexual aids targeting sexual dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.4463","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T14:06:38Z","timestamp":1496153198000},"page":"316-324","source":"Crossref","is-referenced-by-count":44,"title":["Effect of androgen deprivation therapy on sexual function and bother in men with prostate cancer: A controlled comparison"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-8709","authenticated-orcid":false,"given":"Kristine A.","family":"Donovan","sequence":"first","affiliation":[{"name":"Health Outcomes and Behavior Program Moffitt Cancer Center  Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-5735","authenticated-orcid":false,"given":"Brian D.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Health Outcomes and Behavior Program Moffitt Cancer Center  Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley M.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Psychology University of South Florida  Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayer N.","family":"Fishman","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Oncology Moffitt Cancer Center  Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babu","family":"Zachariah","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology James A. 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