{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:20:13Z","timestamp":1791566413880,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:00:00Z","timestamp":1501027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["NCI\u2010NIH P30 CA 16042"],"award-info":[{"award-number":["NCI\u2010NIH P30 CA 16042"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["NCI\u2010NIH P30CA023074"],"award-info":[{"award-number":["NCI\u2010NIH P30CA023074"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["NIH R01 CA133081"],"award-info":[{"award-number":["NIH R01 CA133081"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Create a brief, self\u2010report screener for recently diagnosed breast cancer patients to identify patients at risk of future depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Breast cancer patients (N\u00a0=\u00a0410) within 2\u00a0\u00b1\u00a01\u00a0months after diagnosis provided data on depression vulnerability. Depression outcomes were defined as a high depressive symptom trajectory or a major depressive episode during 16\u00a0months after diagnosis. Stochastic gradient boosting of regression trees identified 7 items highly predictive for the depression outcomes from a pool of 219 candidate depression vulnerability items. Three of the 7 items were from the Patient Health Questionnaire 4 (PHQ\u20104), a validated screener for current anxiety\/depressive disorder that has not been tested to identify risk for future depression. Thresholds classifying patients as high or low risk on the new Depression Risk Questionnaire 7 (DRQ\u20107) and the PHQ\u20104 were obtained. Predictive performance of the DRQ\u20107 and PHQ\u20104 was assessed on a holdout validation subsample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>DRQ\u20107 items assess loneliness, irritability, persistent sadness, and low acceptance of emotion as well as 3 items from the PHQ\u20104 (anhedonia, depressed mood, and worry). A DRQ\u20107 score of \u22656\/23 identified depression outcomes with 0.73 specificity, 0.83 sensitivity, 0.68 positive predictive value, and 0.86 negative predictive value. A PHQ\u20104 score of \u22653\/12 performed moderately well but less accurately than the DRQ\u20107 (net reclassification improvement\u00a0=\u00a010%; 95% CI [0.5\u201316]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The DRQ\u20107 and the PHQ\u20104 with a new cutoff score are clinically accessible screeners for risk of depression in newly diagnosed breast cancer patients. Use of the screener to select patients for preventive interventions awaits validation of the screener in other samples.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.4472","type":"journal-article","created":{"date-parts":[[2017,6,10]],"date-time":"2017-06-10T01:24:44Z","timestamp":1497057884000},"page":"420-426","source":"Crossref","is-referenced-by-count":23,"title":["Predicting future major depression and persistent depressive symptoms: Development of a prognostic screener and PHQ\u20104 cutoffs in breast cancer patients"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5985-8560","authenticated-orcid":false,"given":"Karen L.","family":"Weihs","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Arizona  Tucson Arizona USA"},{"name":"University of Arizona Cancer Center  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua F.","family":"Wiley","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences Monash University  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Crespi","sequence":"additional","affiliation":[{"name":"Department of Psychology University of California  Los Angeles California USA"},{"name":"Department of Biostatistics University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Krull","sequence":"additional","affiliation":[{"name":"Department of Psychology University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette L.","family":"Stanton","sequence":"additional","affiliation":[{"name":"Department of Psychology University of California  Los Angeles California USA"},{"name":"Departments of Psychiatry and Biobehavioral Sciences University of California  Los Angeles California USA"},{"name":"Jonsson Comprehensive Cancer Center University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4037"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1820"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3471-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2749-x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1204"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.5526"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110307"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.12.043"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28750"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713002079"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt175"},{"issue":"12","key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1001\/archpsyc.65.12.1368","article-title":"Development and validation of an international risk prediction algorithm for episodes of major depression in general practice attendees: the PredictD study","volume":"65","author":"King M","year":"2008","journal-title":"Arch Gen Psychiatry"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2013-202845"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-0971-x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716000349"},{"key":"e_1_2_6_17_1","volume-title":"Supportive Care Cancer","author":"Weihs K","year":"2016"},{"key":"e_1_2_6_18_1","first-page":"286","volume-title":"Emotions: Current Issues and Future Directions","author":"Barrett L","year":"2001"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.3.022806.091520"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-0698"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.168"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3563-4"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6601_2"},{"key":"e_1_2_6_25_1","unstructured":"International Personality Item Pool: A Scientific Collaboratory for the Development of Advanced Measures of Personality Traits and Other Individual Differences(http:\/\/ipip.ori.org\/). 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