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Neuroticism and introversion were hypothesized to be associated with clinically significant symptoms of emotional distress, including depression, anxiety, and suicidal ideation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Men with a history of prostate cancer (<jats:italic>n<\/jats:italic>\u00a0=\u00a0212) completed an NIH\u2010funded cross\u2010sectional study using well\u2010validated measures of personality, depression, anxiety, and suicidal ideation. Covariates were age, education, time since diagnosis, comorbidity, and presence of metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Emotional distress was reported by 37% of participants, including depression (23%), anxiety (15%), and suicidal ideation (10%). As hypothesized, men who were more neurotic were more likely to report emotional distress (44.5% vs 26.9%; <jats:italic>OR<\/jats:italic>\u00a0=\u00a02.78, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004), depression (31.9% vs 11.8%; <jats:italic>OR<\/jats:italic>\u00a0=\u00a04.23, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001), and suicidal ideation (29.4% vs 9.7%; <jats:italic>OR<\/jats:italic>\u00a0=\u00a04.15, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). Introverts were more likely to report emotional distress (45.2% vs 28.7%; <jats:italic>OR<\/jats:italic>\u00a0=\u00a02.32, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.012) and depression (30.8% vs 15.7%; <jats:italic>OR<\/jats:italic>\u00a0=\u00a02.57, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.014). Men with metastases were more likely to report emotional distress (51.7% vs 31.2%; <jats:italic>OR<\/jats:italic>\u00a0=\u00a04.56, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neuroticism and introversion were associated with clinically significant emotional distress in men with prostate cancer. Findings suggest that, in the context of treatment for prostate cancer, patient distress reflects disease characteristics (eg, metastases presence) as well as stable personality traits. Implications for clinical care are discussed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.4579","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T12:52:37Z","timestamp":1510318357000},"page":"810-816","source":"Crossref","is-referenced-by-count":29,"title":["Understanding the distressed prostate cancer patient: Role of personality"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6144-6266","authenticated-orcid":false,"given":"Laura M.","family":"Perry","sequence":"first","affiliation":[{"name":"Tulane University  New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hoerger","sequence":"additional","affiliation":[{"name":"Tulane University  New Orleans LA USA"},{"name":"Tulane Cancer Center  New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Silberstein","sequence":"additional","affiliation":[{"name":"Tulane University  New Orleans LA USA"},{"name":"Tulane Cancer Center  New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Sartor","sequence":"additional","affiliation":[{"name":"Tulane University  New Orleans LA USA"},{"name":"Tulane Cancer Center  New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6882-0898","authenticated-orcid":false,"given":"Paul","family":"Duberstein","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Cancer Treatment and Survivorship Facts & Figures 2014\u20132015","author":"Society AC","year":"2014"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28880"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-006674"},{"issue":"2","key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1037\/a0036513","article-title":"Tertiary prevention in cancer care understanding and addressing the psychological dimensions of cancer during the active treatment period","volume":"70","author":"Jacobsen PB","year":"2015","journal-title":"Am Psychol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20193"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3391"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3909"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3751"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2793-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2010.0034"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.52.1.81"},{"issue":"1999","key":"e_1_2_6_13_1","first-page":"102","article-title":"The Big Five trait taxonomy: history, measurement, and theoretical perspectives","volume":"2","author":"John OP","year":"1999","journal-title":"Handbook of personality: Theory and research"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291714000257"},{"key":"e_1_2_6_15_1","unstructured":"DubersteinP P\u00e1lssonS Sj\u00f6grenM WaernM SkoogI.Neuroticism increases risk for first lifetime episodes of depression in a birth cohort of 70 year olds followed for 15 years: the G\u00f6teborg longitudinal study. 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