{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T18:04:17Z","timestamp":1783706657658,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01\u2010CA195547"],"award-info":[{"award-number":["U01\u2010CA195547"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01\u2010MH085849"],"award-info":[{"award-number":["R01\u2010MH085849"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prevalence of emotional, behavioral, and psychiatric outcomes in child and adolescent survivors of childhood acute lymphoblastic leukemia treated on a chemotherapy\u2010only protocol were not well defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Self\u2010 and parent\u2010reported emotional and behavioral symptoms were assessed for 161 survivors of childhood acute lymphoblastic leukemia (51.0% female; mean [SD] age 12.1[2.6] years; 7.5[1.6] years post\u2010diagnosis). Age\u2010 and sex\u2010adjusted scores were calculated for standardized measures and compared with 90th percentile of norms. Frequencies of survivor psychiatric disorders from structured diagnostic interviews with parents were compared with the general population. Parent emotional distress and post\u2010traumatic stress symptoms were assessed. Associations between child symptoms\/disorders and parent distress were examined with log\u2010binomial models, adjusting for highest parent education.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with population expectations (10%), more survivors self\u2010reported symptoms of inattention (27.9; 95% CI, 21.0%\u201035.7%), hyperactivity\/impulsivity (26.0%; CI, 19.2%\u201033.6%), and oppositional\u2010defiant behavior (20.1%; CI, 14.1%\u201027.3%). Parents reported survivors with more symptoms of inattention (23.6%; CI, 17.2%\u201031.0%), higher frequencies of obsessive\u2010compulsive disorder (10.3% vs 2%) and oppositional defiant disorder (16.0% vs 9.5%), but not attention\u2010deficit\/hyperactivity disorder (7.1% vs 7.8%) or generalized anxiety disorder (3.2% vs 4.1%), compared with national norms. Parent\u2010report of child anxiety disorders was associated with parent self\u2010reported emotional distress but not survivor self\u2010report of anxiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A significant minority of survivors have long\u2010term psychiatric morbidity, multi\u2010informant assessment is important to understand these symptom profiles and to inform selection of appropriate interventions. Interventions targeting inattention and oppositional behavior in children and emotional distress in parents are warranted in families with survivors who display behavioral problems.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.4699","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T11:36:35Z","timestamp":1520595395000},"page":"1597-1607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Behavioral symptoms and psychiatric disorders in child and adolescent long\u2010term survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only"],"prefix":"10.1002","volume":"27","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Departments of Biostatistics St. Jude Children's Research Hospital  Memphis TN USA"},{"name":"School of Public Health University of Memphis  Memphis TN 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