{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T10:14:09Z","timestamp":1774606449886,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000135","name":"NIH Blueprint for Neuroscience Research","doi-asserted-by":"publisher","award":["KL2 TR001100"],"award-info":[{"award-number":["KL2 TR001100"]}],"id":[{"id":"10.13039\/100000135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 CA210170 (PI Goggins)"],"award-info":[{"award-number":["U01 CA210170 (PI Goggins)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Describe relationships between self\u2010reported personal demographics or familial characteristics and psychosocial outcomes (Patient Reported Outcome Measurement Information System Global Health, Impact of Event Scale\u2010Revised [pancreatic cancer risk\u2013related distress], cancer risk perception, and cancer worry) in participants with inherited or familial pancreatic cancer risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multisite cross sectional survey of adults with elevated pancreatic cancer risk based on family history. All variables were summarized with descriptive statistics. To assess univariate associations, <jats:italic>t<\/jats:italic> test and chi\u2010square\/Fisher's exact test were used, and backward model selection was used in multivariable analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Respondents (N\u00a0=\u00a0132) reported moderate to high frequency of cancer worry and 59.3% perceived a 50% or more perceived lifetime risk for pancreatic cancer, which far exceeds objective risk estimates. Cancer worry was associated with female gender (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03) and pancreatic cancer risk specific distress (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.05). Higher\u2010risk perception was associated with having a high school education or less (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001), higher distress (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), and cancer worry (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.008) and family cancer death experience (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). Higher distress was associated with experience as a caregiver to a seriously ill family member in the past 5\u00a0years (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Individuals with inherited or familial pancreatic cancer risk experience cancer worry, distress, and have increased risk perception, particularly in the period following caring for a loved one with cancer. Routine evaluation of distress in this setting, as well as the development of supportive care resources, will help support patients living with risk for pancreatic cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.4712","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T15:14:46Z","timestamp":1521818086000},"page":"1711-1718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Relationship between individual and family characteristics and psychosocial factors in persons with familial pancreatic cancer"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1433-5915","authenticated-orcid":false,"given":"Meghan","family":"Underhill","sequence":"first","affiliation":[{"name":"The Phyllis F. 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