{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T19:23:06Z","timestamp":1750015386727,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1R01CA162401\u201001A1"],"award-info":[{"award-number":["1R01CA162401\u201001A1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This manuscript assesses association between depressive symptoms and symptoms from cancer and its treatment during the first 12\u00a0weeks of a new oral oncolytic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This secondary analysis used data from a recently completed trial of an intervention to improve adherence to oral oncolytic treatment and manage symptoms. Following the initiation of the new oral oncolytic medication, 272 patients were interviewed at intake and weeks 4, 8, and 12 to assess depressive symptoms, and symptoms from cancer and its treatment. Depressive symptoms were measured using the Center for Epidemiologic Studies\u2010Depression (CES\u2010D20). The summed index of 18 cancer\u2010related and treatment\u2010related symptoms as well as the number of symptoms above threshold at intake, weeks 4, 8, and 12 were related to intake and time\u2010varying CES\u2010D20 using linear mixed effects models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Depressive symptomatology was a significant predictor of cancer\u2010related and treatment\u2010related symptoms at all\u2010time points, but the strength of this relationship was greatest at the time of oral oncolytic agent initiation and at week 4. The strength of this relationship was the same for both summed symptom severity index and the number of symptoms above threshold, and using either intake or time\u2010varying CES\u2010D20.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Introducing strategies to treat and manage symptoms of depression along with other symptoms might have added benefits among patients who start a new oral oncolytic treatment and report modest to higher levels of depressive symptoms. Assessments for the impact of strategies to lower depressive symptoms can be taken within the first 4\u00a0weeks.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.4916","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T14:54:31Z","timestamp":1539356071000},"page":"99-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of depressive symptomatology on cancer\u2010related symptoms during oral oncolytic treatment"],"prefix":"10.1002","volume":"28","author":[{"given":"Veronica","family":"Decker","sequence":"first","affiliation":[{"name":"College of Nursing University of Central Florida  Orlando FL United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alla","family":"Sikorskii","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Department of Statistics and Probability Michigan State University  East Lansing MI United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7478-2621","authenticated-orcid":false,"given":"Charles W.","family":"Given","sequence":"additional","affiliation":[{"name":"College of Nursing Michigan State University  East Lansing MI United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3971-214X","authenticated-orcid":false,"given":"Barbara A.","family":"Given","sequence":"additional","affiliation":[{"name":"College of Nursing Michigan State University  East Lansing MI United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Vachon","sequence":"additional","affiliation":[{"name":"College of Nursing Michigan State University  East Lansing MI United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Krauss","sequence":"additional","affiliation":[{"name":"Hematology Oncology University of Michigan  Ann Arbor MI United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2016.1266090"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.2944"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.0541"},{"key":"e_1_2_8_5_1","article-title":"Antidepressants for the treatment of depression in people with cancer","volume":"6","author":"Ostuzzi G","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.07.101"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2793-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.14.2101"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(14)70313-X"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2012.645804"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-007-9841-z"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291709992285"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2014.12.011"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.505"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.12.139"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4160"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00168-6"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-0179-3-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.7372"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1695"},{"key":"e_1_2_8_21_1","unstructured":"National Comprehensive Cancer Network.NCCN clinical practice guidelines in Oncology Version 2.2016;2016. 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