{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:49:59Z","timestamp":1761648599550,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute of Nursing Research of the National Institutes of Health","award":["R01NR014195"],"award-info":[{"award-number":["R01NR014195"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Impaired neurocognitive function (NCF) is a well\u2010established consequence of pediatric medulloblastoma (MB) and its treatments. However, the frequency and features of neurocognitive dysfunction in adult\u2010onset MB patients are largely unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult patients (\u2265 18\u00a0years) with MB who had received formal neurocognitive evaluation (<jats:italic>N<\/jats:italic>\u00a0=\u00a027) were identified. Demographic, medical, and treatment histories were extracted from the medical record. Lesion properties on MRI were analyzed and used to evaluate lesion\u2010symptom mapping further. Demographically adjusted z\u2010scores were calculated for each neurocognitive test and used to assess impairment frequency. Regression analyses were conducted to identify clinical and paraclinical factors associated with impaired NCF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age of the patient sample was 33\u00a0years (SD\u00a0=\u00a011) at the time of MB diagnosis. Prior therapy included surgical resection (89%), radiation (70%), and chemotherapy (26%). A significant proportion of patients were impaired on tests of verbal learning and memory (32%), executive function (29%), and naming (18%). Age, education, lesion size, time from surgery, and number of chemotherapy cycles had the greatest contribution to test performance in random\u2010forest regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study identifies frequent impairment of NCF in adult patients with MB, particularly in the domains of learning and memory and executive function. Neurocognitive impairment is influenced by patients' demographic, disease, and treatment history. Further study is warranted to characterize the clinical impact of adult MB more fully.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.4920","type":"journal-article","created":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T12:34:09Z","timestamp":1539434049000},"page":"131-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Neurocognitive dysfunction in adult cerebellar medulloblastoma"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5689-8492","authenticated-orcid":false,"given":"Rebecca A.","family":"Harrison","sequence":"first","affiliation":[{"name":"Department of Neuro\u2010Oncology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelli R.","family":"Kesler","sequence":"additional","affiliation":[{"name":"Section of Neuropsychology, Department of Neuro\u2010Oncology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Radiology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Penas\u2010Prado","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine M.","family":"Sullaway","sequence":"additional","affiliation":[{"name":"Section of Neuropsychology, Department of Neuro\u2010Oncology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S.","family":"Wefel","sequence":"additional","affiliation":[{"name":"Section of Neuropsychology, Department of Neuro\u2010Oncology 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