{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T21:25:35Z","timestamp":1793568335758,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24 DA045244"],"award-info":[{"award-number":["K24 DA045244"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA165001"],"award-info":[{"award-number":["R01 CA165001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Continuing to smoke after a cancer diagnosis undermines prognosis. Yet few trials have tested Food and Drug Administration (FDA)\u2010approved tobacco use medications in this population. Extended use varenicline may represent an effective treatment for cancer patients who smoke given barriers to cessation including a prolonged time line for relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A placebo\u2010controlled randomized trial tested 12\u00a0weeks of varenicline plus 12\u00a0weeks of placebo (standard [ST]) vs 24\u00a0weeks of varenicline (extended [ET]) with seven counseling sessions for treatment\u2010seeking cancer patients who smoke (N\u00a0=\u00a0207). Primary outcomes were 7\u2010day biochemically confirmed abstinence at weeks 24 and 52. Treatment adherence and side effects, adverse and serious adverse events, and blood pressure were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Point prevalence and continuous abstinence quit rates at weeks 24 and 52 were not significantly different across treatment arms (<jats:italic>P<\/jats:italic>'s\u00a0&gt;\u00a00.05). Adherence (43% of sample) significantly interacted with treatment arm for week 24 point prevalence (odds ratio [OR]\u00a0=\u00a02.31; 95% confidence interval [CI], 1.15\u20104.63; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and continuous (OR\u00a0=\u00a05.82; 95% CI, 2.66\u201012.71; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) abstinence. For both outcomes, adherent participants who received ET reported higher abstinence (60.5% and 44.2%) vs ST (44.7% and 27.7%), but differences in quit rates between arms were not significant for nonadherent participants (ET: 9.7% and 4.8%; ST: 12.7% and 10.9%). There were no significant differences between treatment arms on side effects, adverse and serious adverse events, and rates of high blood pressure (<jats:italic>P<\/jats:italic>'s\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with ST, ET varenicline does not increase patient risk and increases smoking cessation rates among patients who adhere to treatment. Studies are needed to identify effective methods to increase medication adherence to treat patient tobacco use effectively.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.4978","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T05:29:41Z","timestamp":1548394181000},"page":"561-569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["A randomized controlled trial of 24\u00a0weeks of varenicline for tobacco use among cancer patients: Efficacy, safety, and adherence"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4089-856X","authenticated-orcid":false,"given":"Robert","family":"Schnoll","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Leone","sequence":"additional","affiliation":[{"name":"Pulmonary, Allergy, and Critical Care Division University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Veluz\u2010Wilkins","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Miele","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Hole","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy C.","family":"Jao","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Paul Wileyto","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3576-8808","authenticated-orcid":false,"given":"Allison J.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Kalhan","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University  Chicago Illinois"},{"name":"Department of Medicine Northwestern University  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Chicago  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Langer","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Fen","family":"Lubitz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Hitsman","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Feinberg School of Medicine, and Robert H. Lurie Comprehensive Cancer Center of Northwestern University  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28695"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0104"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0666"},{"key":"e_1_2_14_5_1","unstructured":"HowladerN NooneAM KrapchoM et al.SEER Cancer Statistics Review 1975\u20102012 National Cancer Institute. Bethesda MD https:\/\/seer.cancer.gov\/csr\/1975_2012\/ based on November 2014 SEER data submission posted to the SEER web site April 2015."},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318288dc96"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2008.05.006"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2008.10.014"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2007.112060"},{"issue":"4","key":"e_1_2_14_10_1","first-page":"S555","article-title":"Time to first cigarette in the morning as an index of ability to quit smoking: implications for nicotine dependence","volume":"9","author":"Transdisciplinary Tobacco Use Research Center Tobacco","year":"2007","journal-title":"Nicotine Tob Res"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15324796abm3001_1"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9507-8"},{"key":"e_1_2_14_13_1","first-page":"261","article-title":"Predictors of long\u2010term smoking cessation in head and neck cancer patients","volume":"2","author":"Gritz ER","year":"1993","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-200411000-00008"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2007.09.013"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11538"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802415535"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgh026"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2004.00540.x"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27880"},{"key":"e_1_2_14_21_1","first-page":"CD006103","article-title":"Nicotine receptor partial agonists for smoking cessation","author":"Cahill K","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.08.028"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.05.033"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-3-201002020-00005"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318215a4dc"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4166"},{"key":"e_1_2_14_27_1","first-page":"1217","article-title":"Treating tobacco use and dependence: 2008 update US Public Health Service Clinical Practice Guideline executive summary","volume":"53","author":"Fiore MC","year":"2008","journal-title":"Respir Care"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/nty133"},{"issue":"20","key":"e_1_2_14_29_1","first-page":"22","article-title":"The Mini\u2010International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM\u2010IV and ICD\u201010","volume":"59","author":"Sheehan DV","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70294-2"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1991.tb01879.x"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1037\/0893-164X.12.2.101"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abrep.2018.06.006"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/1462220031000070552"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/14622200210123581"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30272-0"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/14622200500055673"},{"key":"e_1_2_14_38_1","article-title":"Adherence to pharmacological smoking cessation interventions: a literature review and synthesis of correlates and barriers","author":"Pacek LR","year":"2017","journal-title":"Nicotine Tob Res"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(14)70313-X"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.19284"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2017.07.006"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpon.4978","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.4978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T19:02:23Z","timestamp":1694286143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.4978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,24]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/pon.4978"],"URL":"https:\/\/doi.org\/10.1002\/pon.4978","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,24]]},"assertion":[{"value":"2018-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}