{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T23:24:04Z","timestamp":1783207444701,"version":"3.54.6"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grants-in-Aid for Scientific Research from the Japanese Society for the Promotion of Science","award":["24616008"],"award-info":[{"award-number":["24616008"]}]},{"name":"Grants-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare","award":["201221008"],"award-info":[{"award-number":["201221008"]}]},{"name":"Grants-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare","award":["201221057"],"award-info":[{"award-number":["201221057"]}]},{"name":"Grants-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare","award":["201311007"],"award-info":[{"award-number":["201311007"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of the study is to investigate depressive symptoms before and after the initiation of chemotherapy and their impact on overall survival (OS) among patients with hematological malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a prospective analysis of consecutive patients with newly diagnosed malignant lymphoma or multiple myeloma enrolled between September 2010 and March 2016. We evaluated depression symptoms at two time points: before starting chemotherapy (T1) and 1\u00a0month later (T2), using PHQ\u20109 and known prognostic factors. We allocated participants with depressive symptoms at T1 and\/or T2 to a depression group that was subdivided as follows: new depressive symptoms at T2, (\u201cnew\u2010onset\u201d), remission of depressive symptoms at T2 (\u201cremission\u201d), and persistent depressive symptoms from T1 to T2 (\u201cpersistent\u201d). The main outcome, OS, was evaluated using Kaplan\u2010Meier methods and multivariate Cox proportional hazards modeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 294 eligible participants, we analyzed 255 patients, including 83 with depression. There were 19 participants in the new\u2010onset, 38 in the remission, and 26 in the persistent depression group. The OS of participants with depression was significantly shorter than that of those without depression (adjusted hazard ratio [AjHR] 2.43; 95% confidence interval [CI] 1.43\u20104.12; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Using the never\u2010depressive symptoms group as a reference group, AjHRs were as follows: new\u2010onset, 1.91 (95% CI, 0.77\u20104.75; 0.166); remission, 2.98 (95% CI, 1.55\u20105.74; 0.001), and persistent, 2.17 (95%CI, 1.01\u20104.68; 0.047).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among patients with mature lymphoid malignancy, the group with depression at baseline had a poorer survival, both in the group that remained depressive and the group that recovered from depressive symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.5143","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T04:02:07Z","timestamp":1562126527000},"page":"1687-1694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Depressive symptoms during the first month of chemotherapy and survival in patients with hematological malignancies: A prospective cohort study"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7894-4528","authenticated-orcid":false,"given":"Takaaki","family":"Hasegawa","sequence":"first","affiliation":[{"name":"Division of Psycho\u2010oncology and Palliative Care Nagoya City University Hospital  Nagoya Japan"},{"name":"Department of Psychiatry and Cognitive\u2010Behavioral Medicine Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0504-6406","authenticated-orcid":false,"given":"Toru","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Division of Psycho\u2010oncology and Palliative Care Nagoya City University Hospital  Nagoya Japan"},{"name":"Department of Psychiatry and Cognitive\u2010Behavioral Medicine Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-8400","authenticated-orcid":false,"given":"Megumi","family":"Uchida","sequence":"additional","affiliation":[{"name":"Division of Psycho\u2010oncology and Palliative Care Nagoya City University Hospital  Nagoya Japan"},{"name":"Department of Psychiatry and Cognitive\u2010Behavioral Medicine Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayo","family":"Aiki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Cognitive\u2010Behavioral Medicine Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"},{"name":"Department of Palliative Care National Hospital Organization Osaka National Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6196-8742","authenticated-orcid":false,"given":"Fuminobu","family":"Imai","sequence":"additional","affiliation":[{"name":"Division of Psycho\u2010oncology and Palliative Care Nagoya City University Hospital  Nagoya Japan"},{"name":"Department of Psychiatry and Cognitive\u2010Behavioral Medicine Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0549-050X","authenticated-orcid":false,"given":"Masahiro","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Division of Psycho\u2010oncology and Palliative Care Nagoya City University Hospital  Nagoya Japan"},{"name":"Department of Psychiatry and Cognitive\u2010Behavioral Medicine Nagoya City University Graduate School of Medical Sciences  Nagoya 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1627-3743","authenticated-orcid":false,"given":"Hirokazu","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kusumoto","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ri","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Osaga","sequence":"additional","affiliation":[{"name":"Clinical Research 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