{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:54:39Z","timestamp":1793501679843,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Female carriers of <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>BRCA2<\/jats:italic> mutations (BRCAm) are at increased risk of developing breast and ovarian cancer. The main prevention options currently available consist in either clinical\u2010radiological surveillance or risk\u2010reducing surgery. This study investigated factors that might influence the choice of risk\u2010reducing mastectomy (RRM) and\/or salpingo\u2010oophorectomy (RRSO) over surveillance in high\u2010risk women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred twenty\u2010eight BRCAm women, 75 (58.60%) cancer affected (C\u2010A) and 53 (41.40%) cancer\u2010unaffected (C\u2010UN), completed a baseline questionnaire concerning socio\u2010demographic factors, personal medical history, cancer family history, and psychological dimensions. Preferences about prevention strategies were evaluated after 15\u00a0months. Multivariate logistic regression was used to analyse the relationship between these factors and the choice of RRSO or RRM in the whole cohort and the choice of surgery (RRM and\/or RRSO) in C\u2010A and C\u2010UN women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analyses on the whole cohort highlighted factors associated with the choice of both RRM and RRSO (\u201ccancer concern,\u201d \u201cprevious therapeutic mastectomy,\u201d and \u201cnumber of cancer\u2010affected family members\u201d), but also a few specifically associated with either RRM (age) or RRSO (\u201chealth\u201d and \u201cenergy\u201d perception and \u201cnumber of children\u201d). Surgery was more likely to be chosen by C\u2010A (76%) than C\u2010UN women (34%). With the exception of \u201ccancer concern,\u201d factors associated with the choice of surgery were different between C\u2010A (\u201cnumber of deaths for cancer in the family\u201d and \u201cfeeling downhearted and blue\u201d) and C\u2010UN (\u201cnumber of children\u201d and \u201chealth perception\u201d) women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights potential drivers underlying the choice of preventive surgery, which should be considered when supporting the decision\u2010making process in these women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.5166","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T05:54:42Z","timestamp":1562046882000},"page":"1871-1878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Risk\u2010reducing surgery in <i>BRCA1<\/i>\/<i>BRCA2<\/i> mutation carriers: Are there factors associated with the choice?"],"prefix":"10.1002","volume":"28","author":[{"given":"Siranoush","family":"Manoukian","sequence":"first","affiliation":[{"name":"Unit of Medical Genetics, Department of Medical Oncology and Hematology Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2183-240X","authenticated-orcid":false,"given":"Sara","family":"Alfieri","sequence":"additional","affiliation":[{"name":"Clinical Psychlogy Unit Fondazione IRCSS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Clinical Psychlogy Unit Fondazione IRCSS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Peissel","sequence":"additional","affiliation":[{"name":"Unit of Medical Genetics, Department of Medical Oncology and Hematology Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Azzollini","sequence":"additional","affiliation":[{"name":"Unit of Medical Genetics, Department of Medical Oncology and Hematology Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Borreani","sequence":"additional","affiliation":[{"name":"Clinical Psychlogy Unit Fondazione IRCSS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/375033"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt095"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.7112"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4532-1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10020057"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000239105.39149.d8"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603725"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107193450301"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1237"},{"issue":"7","key":"e_1_2_11_11_1","first-page":"3","article-title":"Time to decide about risk\u2010reducing mastectomy: a case series of BRCA1\/2 gene mutation carriers. 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