{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:52:50Z","timestamp":1747151570642,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","award":["16\u20100875"],"award-info":[{"award-number":["16\u20100875"]}],"id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between prophylactic bilateral oophorectomy and use of antidepressants in women with a <jats:bold>family history of<\/jats:bold> cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nationwide population\u2010based cohort study using Danish National Registries including women oophorectomized due to a <jats:bold>family history of<\/jats:bold> cancer (n = 2,002) and an age matched reference group (n = 18,018). Analyses were stratified by age at time of bilateral oophorectomy and use of hormone replacement therapy (HRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women oophorectomized at age \u2264\u200945\u2009years were more likely to use antidepressants from the first year after bilateral oophorectomy (OR = 1.34; 95 % CI: 1.08\u20101.65) compared to the reference group. Women oophorectomized at age 46\u201055\u2009years and at age &gt;55\u2009years had no significantly increased use of antidepressants (OR = 0.90; 95 % CI: 0.68\u20101.18 and OR = 1.14; 95 % CI: 0.81\u20101.61). The increased use of antidepressants in women oophorectomized at age \u2264\u200945\u2009years was limited to women treated with HRT (OR = 1.51; 95 % CI: 1.18\u20101.94) whereas women oophorectomized at age \u2264\u200945\u2009years not treated with HRT had no increased use of antidepressants (OR = 1.03; 95 % CI: 0.70\u20101.51).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women oophorectomized due to a <jats:bold>family history of<\/jats:bold> cancer at age \u2264\u200945\u2009years were more likely to use antidepressants after bilateral oophorectomy. The increased use of antidepressants was limited to women treated with HRT. The study calls for further large\u2010scale studies to understand how bilateral oophorectomy and concomitant HRT affects risk of depression in women with a <jats:bold>family history of<\/jats:bold> cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.5290","type":"journal-article","created":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T13:54:26Z","timestamp":1573912466000},"page":"655-662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of antidepressants in women after prophylactic bilateral oophorectomy: A Danish national cohort study"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1317-7051","authenticated-orcid":false,"given":"Julie","family":"Abildgaard","sequence":"first","affiliation":[{"name":"The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet University of Copenhagen  Copenhagen 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