{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:40:46Z","timestamp":1791985246157,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Cancer diagnosis in adolescents and young adults (AYAs) coincides with the developmental initiation of substance use and emergence of affective disturbance. We examined substance use behaviors and risk\u2010stratified associations with mental and physical health, as well as objective indicators of tobacco and cannabis use and concordance with self\u2010report and medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>AYAs were 15 to 39\u2009years at cancer diagnosis and \u226518\u2009years and \u22656 months postdiagnosis at study enrollment. Risk\u2010stratified groups included nonsmoker\/nondrinker, nonsmoker\/drinker, smoker\/drinker. Assessments included demographics, past year tobacco, alcohol, and cannabis use, depression, anxiety, sleep, and physical activity. Urine analysis provided biochemical verification of tobacco and cannabis use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants included 100 AYAs (60% male) with primarily hematological cancers (88%). Past year alcohol, tobacco, and cannabis use prevalence rates were 80%, 15%, and 33%, respectively. A minority (non\u2010users) refrained from both alcohol and tobacco (20%), while most were exclusively alcohol users (65%) or alcohol and tobacco co\u2010users (15%). Relative to other sub\u2010groups, co\u2010users reported more depressive and anxious symptoms, while non\u2010users reported more physical activity. More frequent tobacco and cannabis use were associated with more depressive and anxious symptoms, while more frequent alcohol use was associated with lower physical activity. There were no group differences or associations with sleep quality. There was considerable discordance between tobacco use self\u2010report, biochemical verification, and medical record documentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Substance use among AYAs is common and detrimental to mental and physical health, especially among more frequent users and co\u2010users, highlighting the need for early assessment and intervention.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.5378","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T13:22:23Z","timestamp":1583846543000},"page":"1068-1076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Substance use behaviors in adolescent and young adult cancer patients: Associations with mental and physical health"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7660-6250","authenticated-orcid":false,"given":"Yasmin","family":"Asvat","sequence":"first","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Neuroscience University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea C.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Neuroscience University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Data Science Fudan University  Shanghai, China USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Hedeker","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences and College University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara O.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Adolescents and Young Adults with Cancer [Internet]","author":"National Cancer Institute","year":"2018"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2010.0005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/103032"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4351"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.47.3173"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-013-0559-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.55.5.469"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2015.05.006"},{"key":"e_1_2_8_10_1","volume-title":"Key Substance Use and Mental Health Indicators in the United States: Results from the 2015 National Survey on Drug Use and Health","author":"Center for Behavioral Health Statistics and Quality","year":"2016"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1188\/15.CJON.19-06AP"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27445"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1037\/11381-006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e3283477a09"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.6175"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30086"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2015.0035"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25943"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30417"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-015-0474-7"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559827609338148"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.5993\/AJHB.34.1.9"},{"key":"e_1_2_8_23_1","unstructured":"Substance Abuse and Mental Health Services Administration.Key substance use and mental health indicators in the United States: results from the 2017 National Survey on Drug Use and Health. 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