{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:19:00Z","timestamp":1788920340512,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009794","name":"Breast Cancer Now","doi-asserted-by":"publisher","award":["2015CR_004"],"award-info":[{"award-number":["2015CR_004"]}],"id":[{"id":"10.13039\/100009794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Troublesome hot flushes and night sweats (HFNS) are experienced by many women after treatment for breast cancer, impacting significantly on sleep and quality of life. Cognitive behavioural therapy (CBT) is known to be effective for the alleviation of HFNS. However, it is not known if it can effectively be delivered by specialist nurses. We investigated whether group CBT, delivered by breast care nurses (BCNs), can reduce the impact of HFNS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited women with primary breast cancer following primary treatment with seven or more HFNS\/week (including 4\/10 or above on the HFNS problem rating scale), from six UK hospitals to an open, randomised, phase 3 effectiveness trial. Participants were randomised to Group CBT or usual care (UC). The primary endpoint was HFNS problem rating at 26\u2009weeks after randomisation. Secondary outcomes included sleep, depression, anxiety and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between 2017 and 2018, 130 participants were recruited (CBT:63, control:67). We found a 46% (6.9\u20103.7) reduction in the mean HFNS problem rating score from randomisation to 26\u2009weeks in the CBT arm and a 15% (6.5\u20105.5) reduction in the UC arm (adjusted mean difference \u22121.96, CI \u22123.68 to \u22120.23,\n                      <jats:italic>P<\/jats:italic>\n                      = .039). Secondary outcomes, including frequency of HFNS, sleep, anxiety and depression all improved significantly.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that specialist nurses can be trained to deliver CBT effectively to alleviate troublesome menopausal hot flushes in women following breast cancer in the NHS setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.5432","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T04:00:21Z","timestamp":1590552021000},"page":"1514-1523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Effectiveness of nurse\u2010led group\n                    <scp>CBT<\/scp>\n                    for hot flushes and night sweats in women with breast cancer: Results of the\n                    <scp>MENOS4<\/scp>\n                    randomised controlled trial"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7347-8919","authenticated-orcid":false,"given":"Deborah","family":"Fenlon","sequence":"first","affiliation":[{"name":"Department Nursing, College of Human and Health Sciences Swansea University  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Maishman","sequence":"additional","affiliation":[{"name":"Southampton Clinical Trials Unit University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Health Services Research and Policy London School of Hygiene &amp; Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Nuttall","sequence":"additional","affiliation":[{"name":"Southampton Clinical Trials Unit University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"May","sequence":"additional","affiliation":[{"name":"Department of Health Services Research and Policy London School of Hygiene &amp; Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Ellis","sequence":"additional","affiliation":[{"name":"Southampton Clinical Trials Unit University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Raftery","sequence":"additional","affiliation":[{"name":"Primary Care and Population Sciences University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Turner","sequence":"additional","affiliation":[{"name":"Southampton Clinical Trials Unit University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Fields","sequence":"additional","affiliation":[{"name":"Ladybird Unit Poole Hospital NHS Trust  Poole UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Southampton Clinical Trials Unit University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myra S.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Psychology Institute of Psychiatry, Psychology and Neuroscience, King's College London  London 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