{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:20:26Z","timestamp":1783941626652,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"The National Cancer Institute","doi-asserted-by":"publisher","award":["5T32CA092408"],"award-info":[{"award-number":["5T32CA092408"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"The National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA112631"],"award-info":[{"award-number":["R01CA112631"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"The National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA215134"],"award-info":[{"award-number":["R01CA215134"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Hematopoietic stem cell transplantation (HSCT) can compromise long\u2010term health and social functioning. We examined the impact of physical and social\u2010emotional factors on the social functioning of long\u2010term adolescent and young adult (AYA) HSCT survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional analysis included HSCT recipients from the INSPIRE trial [NCT00799461] who received their first transplant between ages 15\u201039. Patient\u2010reported outcome measures included the Short Form\u201036v2, Fatigue Symptom Inventory, Cancer and Treatment Distress, and the ENRICHD Social Support Inventory. We used hierarchical multiple linear regression to identify physical and social\u2010emotional factors associated with social functioning at the baseline assessment, with the first block including sociodemographic and clinical factors significant at <jats:italic>P\u2009=<\/jats:italic> &lt;0.10 in univariate testing, the second block including fatigue and physical function, and the third block including social support and distress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants (N = 279) were 52% male and 93.5% white, non\u2010Hispanic, with a mean age of 30.3 (SD 6.6) at first transplant. Social Functioning mean was 48.5 (SD 10.5), below age\u2010adjusted norms (<jats:italic>t<\/jats:italic> =\u2009\u221213.6, <jats:italic>P\u2009=<\/jats:italic> &lt;0.001). In the first block, current chronic graft\u2010vs\u2010host disease accounted for 5.5% of the variance (<jats:italic>P<\/jats:italic> =\u2009&lt;0.001). Adding fatigue and physical function explained an additional 46.6% of the variance (<jats:italic>P<\/jats:italic> =\u2009&lt;0.001). Adding distress and social support explained an additional 7.7% of the variance (<jats:italic>P<\/jats:italic> =\u2009&lt;0.001). The final model explained 59.8% of the variance; distress, fatigue, and physical function were significantly associated with social functioning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Distress, fatigue, and physical function are associated with social functioning and interventions targeting these symptoms may help to improve SF among long\u2010term cancer survivors treated with HSCT as AYAs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.5460","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T13:31:10Z","timestamp":1594042270000},"page":"1579-1586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Factors associated with social functioning among long\u2010term cancer survivors treated with hematopoietic stem cell transplantation as adolescents or young adults"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4926-5301","authenticated-orcid":false,"given":"Casey A.","family":"Walsh","sequence":"first","affiliation":[{"name":"Department of Health Services University of Washington  Seattle Washington USA"},{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean C.","family":"Yi","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7608-607X","authenticated-orcid":false,"given":"Abby R.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Cancer and Blood Disorders Center Seattle Children's Hospital  Seattle Washington USA"},{"name":"Center for Clinical and Translational Research, Palliative Care and Resilience Research Program Seattle Children's Research Institute  Seattle Washington USA"},{"name":"University of Washington Cambia Palliative Care Center of Excellence  Seattle Washington USA"},{"name":"Department of Pediatrics, School of Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Laure V.","family":"Crouch","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy M.","family":"Leisenring","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Syrjala","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center  Seattle Washington USA"},{"name":"Department of Psychiatry and Behavioral Sciences, School of Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"National Cancer Institute.Closing the gap: research and care imperatives for adolescent and young adults with cancer. 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