{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:21:58Z","timestamp":1788009718757,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003975","name":"Israel Cancer Association","doi-asserted-by":"publisher","award":["20170158"],"award-info":[{"award-number":["20170158"]}],"id":[{"id":"10.13039\/501100003975","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To establish and to evaluate the effectiveness of a three\u2010tier screening process of depressive and anxiety disorders among children and adolescents with cancer based on questionnaires (first tier), semistructured psychiatric interviews (second tier), and referral for psychiatric assessment and recommendations for treatment (third tier). We also aimed to determine the rates of depressive and anxiety disorders among participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants and their parents completed the Patient Reported Outcomes Measurement Information System (PROMIS) Depression and Anxiety modules. Then, they were interviewed separately using the semistructured Affective and Anxiety Modules of the Schedule for Affective Disorders and Schizophrenia for School\u2010Age Children (K\u2010SADS). PROMIS cutoff values for diagnosing depressive and anxiety disorders, based on the K\u2010SADS, were calculated by receiver\u2010operating characteristics (ROCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 91 participants 34 (37.4%) aged 7 to 21\u2009years with cancer met the K\u2010SADS criteria for depressive and\/or anxiety disorders. The results of the ROC analyses were stronger for depressive disorders than for anxiety disorders and for more severe cases. The cutoff of 13 on the child\u2010reported PROMIS for a major depressive episode had a sensitivity of 0.80 and a specificity of 0.82, and a cutoff of 14 on the parent\u2010reported PROMIS for generalized anxiety disorder had a sensitivity of 0.78 and a specificity of 0.79.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Using the K\u2010SADS, we found that anxiety and depressive disorders are very common in youngsters with cancer. The three\u2010tier screening process we developed for depression and anxiety in this population provides practical cutoff values for identifying depressive and anxiety disorders in children with cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.5494","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T02:47:45Z","timestamp":1595299665000},"page":"2019-2027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A three\u2010tier process for screening depression and anxiety among children and adolescents with cancer"],"prefix":"10.1002","volume":"29","author":[{"given":"Maya","family":"Yardeni","sequence":"first","affiliation":[{"name":"Pediatric Hemato\u2010Oncology Division Sheba Medical Center Tel Hashomer  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gadi","family":"Abebe Campino","sequence":"additional","affiliation":[{"name":"Pediatric Hemato\u2010Oncology Division Sheba Medical Center Tel Hashomer  Tel Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shira","family":"Bursztyn","sequence":"additional","affiliation":[{"name":"Child Psychiatry Division Edmond and Lily Safra Children's Hospital, Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Shamir","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehud","family":"Mekori \u2013 Domachevsky","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Child Psychiatry Division Edmond and Lily Safra Children's Hospital, Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos","family":"Toren","sequence":"additional","affiliation":[{"name":"Pediatric Hemato\u2010Oncology Division Sheba Medical Center Tel Hashomer  Tel Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9305-5382","authenticated-orcid":false,"given":"Doron","family":"Gothelf","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Child Psychiatry Division Edmond and Lily Safra Children's Hospital, Sheba Medical Center  Tel Hashomer Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"issue":"7","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/pon.1002","article-title":"Depression in paediatric cancer: an overview","volume":"15","author":"DeJong M","year":"2006","journal-title":"Psycho\u2010Oncol: J Psychol, Social Behav Dimen Cancer"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000151803.72219.ec"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29946"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgh014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000181042.29208.eb"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:JOCS.0000016267.21912.74"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28750"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25730"},{"key":"e_1_2_9_10_1","unstructured":"Cancer Surgeons. 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