{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:17:04Z","timestamp":1763018224417,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Cancer survivors commonly experience long\u2010term anxiety and depression. Anxiety and depression might result from problems emerging during survivorship rather than illness and treatment. This study tested three potential causal paths: (a) concerns about physical symptoms and functional problems and fear of cancer recurrence (FCR) arising during survivorship<jats:italic>directly<\/jats:italic>cause anxiety and depression, (b) an<jats:italic>indirect<\/jats:italic>path whereby FCR mediates effects of concerns about physical symptoms and functional problems on anxiety and depression, and (c) a<jats:italic>reciprocal<\/jats:italic>path whereby anxiety and depression cause concerns about physical symptoms and functional problems and FCR, which exacerbate later anxiety and depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sample of 453 uveal melanoma survivors who completed observations 6\u2010, 12\u2010, 24\u2010, 36\u2010, 48\u2010 and 60\u2010months post\u2010diagnosis and did not miss two consecutive observations. Cross\u2010lagged analyses were conducted to predict Hospital Anxiety and Depression Scale subscale scores. Symptoms and functional problems were measured using the EORTC OPT 30 scale, and FCR operationalised by the EORTC OPT 30 worry about recurrence scale. Covariates were age, gender, treatment modality, and visual acuity of the fellow eye and chromosome\u20103 status (which accurately predicts 10\u2010year survival), worry and anxiety or depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All paths received some support, although the indirect path emerged only for anxiety in females. Concerns about physical symptoms, functional problems, and FCR originated in survivorship and appeared to both influence and be influenced by anxiety and depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings emphasise the importance of actively monitoring survivors to prevent, detect, and intervene in the development of anxiety and depression during survivorship.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.5514","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T06:00:17Z","timestamp":1597125617000},"page":"1864-1873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Predictors of long\u2010term anxiety and depression in uveal melanoma survivors: A cross\u2010lagged five\u2010year analysis"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6142-0995","authenticated-orcid":false,"given":"Stephen L.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Psychological Sciences University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter L.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences University of Liverpool Liverpool UK"},{"name":"Clinical Health Psychology Service, Linda McCartney Centre Royal Liverpool and Broadgreen University Hospital NHS Trust UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Hope\u2010Stone","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences University of Liverpool Liverpool UK"},{"name":"Clinical Health Psychology Service, Linda McCartney Centre Royal Liverpool and Broadgreen University Hospital NHS Trust UK"},{"name":"Liverpool Ocular Oncology Centre Royal Liverpool and Broadgreen University Hospital NHS Trust UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumana N.","family":"Hussain","sequence":"additional","affiliation":[{"name":"Liverpool Ocular Oncology Centre Royal Liverpool and Broadgreen University Hospital NHS Trust UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich","family":"Heimann","sequence":"additional","affiliation":[{"name":"Liverpool Ocular Oncology Centre Royal Liverpool and Broadgreen University Hospital NHS Trust UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertil","family":"Damato","sequence":"additional","affiliation":[{"name":"Liverpool Ocular Oncology Centre Royal Liverpool and Broadgreen University Hospital NHS Trust UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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