{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:03:39Z","timestamp":1784873019527,"version":"3.55.0"},"reference-count":80,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Steroids play an essential role in treating pediatric acute lymphoblastic leukemia (ALL). The downside is that these drugs can cause severe side effects, such as adverse psychological reactions (APRs) and sleep problems, which can compromise health\u2010related quality of life. This study aimed to systematically review literature to identify risk factors for steroid\u2010induced APRs and sleep problems in children with ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was performed in six databases. Titles\/abstracts were independently screened by two researchers. Data from each included study was extracted based on predefined items. Risk of bias and level of evidence were assessed, using the Quality in Prognosis Studies tool and the Grading of Recommendations Assessment, Development and Evaluation tool, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four articles were included. APR measurement ranged from validated questionnaires to retrospective record retrieval, sleep measurement included questionnaires or actigraphy. Overall, quality of evidence was very low. Current evidence suggests that type\/dose of steroid is not related to APRs, but might be to sleep problems. Younger patients seem at risk for behavior problems and older patients for sleep problems. No studies describing parental stress or medical history were identified. Genetic susceptibility associations remain to be replicated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on the current evidence, conclusions about risk factors for steroid\u2010induced adverse psychological reactions or sleep problems in children with ALL should be drawn cautiously, since quality of evidence is low and methods of measurement are largely heterogeneous. A standardized registration of steroid\u2010induced APRs\/sleep problems and risk factors is warranted for further studies in children with ALL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.5654","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T05:02:40Z","timestamp":1617771760000},"page":"1009-1028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Risk factors for steroid\u2010induced adverse psychological reactions and sleep problems in pediatric acute lymphoblastic leukemia: A systematic review"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1006-3481","authenticated-orcid":false,"given":"Annelienke M.","family":"van Hulst","sequence":"first","affiliation":[{"name":"Princess Maxima Center  CS Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shosha H. M.","family":"Peersmann","sequence":"additional","affiliation":[{"name":"Princess Maxima Center  CS Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica L. T.","family":"van den Akker","sequence":"additional","affiliation":[{"name":"Erasmus MC\u2010 Sophia Children's Hospital  CE Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda J.","family":"Schoonmade","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam  MB Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marry M.","family":"van den Heuvel\u2010Eibrink","sequence":"additional","affiliation":[{"name":"Princess Maxima Center  CS Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha A.","family":"Grootenhuis","sequence":"additional","affiliation":[{"name":"Princess Maxima Center  CS Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00eble R. L.","family":"van Litsenburg","sequence":"additional","affiliation":[{"name":"Princess Maxima Center  CS Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70114-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.1636"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.10768.1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0902"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.041541"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-001-0319-y"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170259"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-005-0882-8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.66.0761"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24988"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454209358890"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3234-y"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23039"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2018.10.006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-9-25"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5242"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1972135part1694"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.11071009"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.01.010"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2018.09.007"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsz079"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2013.11.004"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.1.85"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/23809000.2016.1168265"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23060"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.09.001"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.727"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3475"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25164"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.13091264"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.11.072"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-4-201302190-00009"},{"key":"e_1_2_8_36_1","unstructured":""},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-2-71"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2454"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.103507"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000535"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-012-1236-1"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-7138(09)60608-7"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13847"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.982"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjh.2016.0253"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22163"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05509.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402673"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950200104"},{"issue":"4","key":"e_1_2_8_50_1","first-page":"11","article-title":"The behavioral correlates of increased platelet monoamine oxidase in children","volume":"2","author":"Messina CA","year":"1989","journal-title":"Neuropsychiatry, Neuropsychology, and Behavioral Neurology"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2005.00415.x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20432"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318257fdac"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.07.006"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.04.093"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2091-12.2012"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25147"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsm110"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.03.026"},{"key":"e_1_2_8_60_1","first-page":"CD008727","article-title":"Hypothalamic\u2010pituitary\u2010adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia","volume":"8","author":"Gordijn MS","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1048"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1056"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.11.6965"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70228-1"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2017-0306"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.8404"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28578"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28165"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12443"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25730"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29946"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05013.x"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04985.x"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2012.01.008"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-019-0668-0"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.8.2477"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.2070"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-10-881961"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.4544"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2010.02.003"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-018-1856-x"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.5654","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pon.5654","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.5654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T05:35:20Z","timestamp":1693287320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.5654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,6]]},"references-count":80,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/pon.5654"],"URL":"https:\/\/doi.org\/10.1002\/pon.5654","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,6]]},"assertion":[{"value":"2020-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}