{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:19:55Z","timestamp":1782260395422,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Study objective<\/jats:title><jats:p>There is a need to explore how patient\u2010tailored integrative oncology (IO) programs reduce emotional distress. This study set out to bridge the IO research gap between non\u2010specific, quality of life\u2010related and specific emotional\u2010related concerns in chemotherapy\u2010treated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This pragmatic, prospective and preference\u2010controlled study examined patients attending an integrative\u2010physician consultation and weekly IO treatments during adjuvant\/neo\u2010adjuvant chemotherapy for localized cancer. Patients choosing to attend \u22654 IO sessions (highly adherent to integrative care, AIC) were compared to low AIC patients using the ESAS (Edmonton Symptom Assessment Scale) anxiety, depression and sleep; and the EORTC QLQ\u2010C30 (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire) emotional functioning scale, at baseline, 6 and 12\u00a0weeks. Emotional distress was assessed by ESAS anxiety and depression, considered as the primary study outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 439 participants, 260 (59%) were high\u2010AIC and 179 low\u2010AIC, both with similar baseline demographic and cancer\u2010related characteristics. At 6 weeks, high\u2010AIC patients reported greater improvement on ESAS sleep (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.044); within\u2010group improvement on ESAS anxiety and; and EORTC emotional functioning. Compared with low\u2010AIC, high\u2010AIC patients showed greater improvement on ESAS depression (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.022) and sleep (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.015) in those with high baseline ESAS anxiety scores (\u22657); and ESAS anxiety (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.049) for patients moderately anxious (4\u20136) at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010AIC was associated with significantly reduced anxiety, depression and sleep severity at 6 weeks, especially those with high\u2010to\u2010moderate baseline anxiety levels. These findings reduce the research gap, suggesting specific emotional\u2010related effects of IO.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.5794","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T08:59:36Z","timestamp":1629968376000},"page":"207-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exploring the effectiveness of a patient\u2010tailored integrative oncology program on emotional distress during chemotherapy for localized cancer"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4058-3672","authenticated-orcid":false,"given":"Eran","family":"Ben\u2010Arye","sequence":"first","affiliation":[{"name":"Integrative Oncology Program The Oncology Service Lin, Carmel, and Zebulun Medical Centers Clalit Health Services  Haifa Israel"},{"name":"Faculty of Medicine Technion\u2010Israel Institute of Technology  Haifa 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