{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T03:06:46Z","timestamp":1782529606721,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate the risk of major depressive disorder (MDD) in adolescent and young adult (AYA) patients with cancer in Japan and identify risk factors for MDD among these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a matched cohort study using a large claims database in Japan. Included patients were aged 15\u201339\u00a0years, newly diagnosed with cancer during 2012\u20132017 and assessable for a follow\u2010up period of 12\u00a0months. Kaplan\u2013Meier estimates and Cox proportional hazards models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for MDD in the AYA patients with cancer versus age\u2010, sex\u2010 and working status\u2010matched cancer\u2010free controls. A subgroups analysis of the AYA patients with cancer was performed to explore MDD risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3559 AYA patients with cancer and 35,590 matched controls were included in the analysis. Adolescent and young adult patients with cancer had a three\u2010fold higher risk for MDD compared with cancer\u2010free controls (HR, 3.12; 95% CI, 2.64\u20133.70). Among cancer categories with &gt;100 patients, patients with multiple cancer categories, including those with metastatic cancer (HR, 6.73, 95% CI, 3.65\u201312.40) and leukemia (HR, 6.30; 95% CI, 3.75\u201310.58), had the greatest MDD risk versus matched controls. Patients who received inpatient chemotherapy as initial treatment had a higher risk for MDD than patients without chemotherapy (HR, 0.43; 95% CI, 0.30\u20130.62).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adolescent and young adult patients in Japan with cancer are at high risk for MDD. Particularly, those with multiple cancer categories, leukemia, and those who receive aggressive anticancer treatments should be monitored closely for symptoms of MDD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.5881","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T04:13:47Z","timestamp":1641788027000},"page":"929-937","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Risk of major depressive disorder in adolescent and young adult cancer patients in Japan"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1100-7518","authenticated-orcid":false,"given":"Tatsuo","family":"Akechi","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Cognitive\u2010Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Mishiro","sequence":"additional","affiliation":[{"name":"Japan Medical Office, Takeda Pharmaceutical Company Limited  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Japan Medical Office, Takeda Pharmaceutical Company Limited  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-393"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(01)00456-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3471-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4133"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110307"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3529"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcsup.2013.07.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70002-X"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgh014"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1191\/02169216302pm507oa"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199705000-00011"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2015.17.2\/epark"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.9222"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0483"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5509"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2019.0097"},{"key":"e_1_2_9_18_1","volume-title":"Closing the Gap: Research and Care Imperatives for Adolescents and Young Adults with Cancer\u2013Report of the Adolescent and Young Adult Oncology\u2010Progress Review Group","author":"U.S. Department of Health and Human Services","year":"2006"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S202432"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4730"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29868"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02019"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051444"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2018.1.146"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.je20090066"},{"key":"e_1_2_9_26_1","unstructured":"AkechiT MishiroI FujimotoS.Major depressive disorder in cancer patients 15\u201339 years with a new diagnosis of cancer from January 2012 to September 2017 in Japan as well as age\u2010matched controls; 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