{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:51:41Z","timestamp":1789498301776,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1124749"],"award-info":[{"award-number":["1124749"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether the existing Multidimensional Impact of Cancer Risk Assessment (MICRA) scale, which assesses impact of receiving genetic test results on individuals being assessed for cancer risk, can be successfully adapted to cancer patients experiencing prolonged waiting for results of germline genome sequencing (GS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients previously diagnosed with likely hereditary cancer (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0250) who were waiting for germline GS results completed questionnaires 3\u00a0months after baseline. We adapted the MICRA to measure anxiety associated with waiting for results, and assessed factor structure, internal consistency, test\u2013retest reliability and construct validation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Factor analysis revealed four factors: distress, positive experience, family support and uncertainty. Internal consistency for each sub\u2010scale was high with the values of Cronbach's alpha for the distress, positive experiences, family support and uncertainty sub\u2010scales 0.92, 0.88, 0.92 and 0.87, respectively. Test\u2013retest reliability was poor, with intra\u2010class correlations of 0.53, 0.13, 0.33 and 0.52 for the four factors, respectively. Construct validation showed large correlations between the MICRA distress and uncertainty sub\u2010scale scores and the Impact of Events score intrusion (0.42 and 0.62, respectively) and IES avoidant thinking sub\u2010scales (0.40 and 0.58, respectively) but not the Hospital Anxiety and Depression Scale sub\u2010scales.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The adapted MICRA identified test\u2010related anxiety and uncertainty in a population of cancer patients waiting for germline GS results. Results suggest that the distress and uncertainty sub\u2010scales of the adapted measure are most useful in this context.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.5908","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:17:46Z","timestamp":1645575466000},"page":"1204-1211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Validation of the multidimensional impact of Cancer Risk Assessment Questionnaire to assess impact of waiting for genome sequencing results"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1570-8872","authenticated-orcid":false,"given":"Megan","family":"Best","sequence":"first","affiliation":[{"name":"Institute for Ethics and Society University of Notre Dame Australia  Broadway New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8009-7735","authenticated-orcid":false,"given":"Christine","family":"Napier","sequence":"additional","affiliation":[{"name":"Cancer Theme Garvan Institute of Medical Research  Darlinghurst New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7746-9649","authenticated-orcid":false,"given":"Timothy","family":"Schlub","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9052-1616","authenticated-orcid":false,"given":"Nicci","family":"Bartley","sequence":"additional","affiliation":[{"name":"Faculty of Science University of Sydney  Sydney New South Wales 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