{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:24:30Z","timestamp":1777983870385,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T00:00:00Z","timestamp":1661558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA 1693398"],"award-info":[{"award-number":["R01 CA 1693398"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K07 CA 218362"],"award-info":[{"award-number":["K07 CA 218362"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study describes the prevalence of suicidal ideation (SI) during acute lymphoblastic leukemia (ALL) therapy and investigates the influence of clinical factors and physical symptoms on SI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Children's Depressive Inventory (CDI\u20102) was administered to ALL patients (diagnosed 2012\u20132017) at start of consolidation, delayed intensification (DI), maintenance cycle 1 (MC1), and maintenance cycle 2 (MC2) in a multi\u2010site study. SI was present if patients endorsed the item \u201cI want to kill myself.\u201d Logistic regression models evaluated associations between SI and sociodemographic factors; depressive symptoms; and below average, average, and above average symptom clusters identified using latent class analysis of pain, nausea, fatigue, and sleep.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a0175) were 51% male, 75% high\u2010\/very high\u2010risk disease, with a median age of 11.2\u00a0years at diagnosis (range: 7\u201318\u00a0years). Overall, 14.9% of patients (75% under age 12\u00a0years) endorsed SI during treatment, including 4% at start of consolidation, 9% at DI, 8% at MC1, and 4% at MC2. Non\u2010Hispanic Other patients were 10.9\u2010times (95% CI: 2.30\u201353.40) more likely than non\u2010Hispanic Whites to endorse SI (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003). The frequency of SI was higher in patients experiencing above average (53.3%) compared to below average (4.1%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003) symptoms. Depressive symptoms were consistently associated with SI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SI during the initial year of childhood ALL was more prevalent in children under the age of 12\u00a0years, from ethnic groups not typically associated with increased risk, and who endorsed increased physical and depressive symptoms. Findings highlight the need for improved screening of mental health problems to mitigate symptoms of distress.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.6014","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T07:30:52Z","timestamp":1660980652000},"page":"1782-1789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Longitudinal investigation of suicidal ideation and associated factors during pediatric acute lymphoblastic leukemia chemotherapy"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9332-181X","authenticated-orcid":false,"given":"Kimberly P.","family":"Raghubar","sequence":"first","affiliation":[{"name":"Department of Pediatrics Section of Psychology Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany","family":"Chambers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Oncology Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan M.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Psychology College for Health, Community and Policy University of Texas at San Antonio  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Oncology Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn","family":"Hockenberry","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Oncology Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Casey","family":"Hooke","sequence":"additional","affiliation":[{"name":"School of Nursing University of Minnesota  Minneapolis Minnesota USA"},{"name":"Children's Minnesota Cancer and Blood Disorders Program  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Mitby","sequence":"additional","affiliation":[{"name":"Children's Minnesota Cancer and Blood Disorders Program  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida Ki","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Nursing University of Arizona  Tuscan Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Oncology Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Scheurer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Oncology Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1400972"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.21.1433"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2017.03.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1188\/10.onf.e16\u2010e27"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454211409586"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28578"},{"key":"e_1_2_10_8_1","unstructured":"Centers for Disease Control and Prevention.WISQARS\u2122 \u2013 Web\u2010Based Injury Statistics Query and Reporting System;2021."},{"key":"e_1_2_10_9_1","unstructured":"Centers for Disease Control and Prevention.Youth Risk Behavior Surveillance System;2021."},{"key":"e_1_2_10_10_1","unstructured":"Centers for Disease Control and Prevention.1995\u20132019 Middle School Youth Risk Behavior Survey Data;2021."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009\u20101814"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15326888chc3403_2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.25.9564"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2000.18.24.4060"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.23.4534"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25773"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2006.06.5409"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29946"},{"key":"e_1_2_10_19_1","volume-title":"Children\u2019s Depression Inventory (CDI2): Technical Manual","author":"Kovacs M","year":"2011"},{"key":"e_1_2_10_20_1","first-page":"9","article-title":"Pain in children: comparison of assessment scales","volume":"14","author":"Wong DL","year":"1988","journal-title":"Pediatr Nurs"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.07.015"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454211418667"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleh.2016.04.001"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12059"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.22.8635"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.01.080"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010013\u20101130\u20106"},{"key":"e_1_2_10_28_1","first-page":"1","volume-title":"Death Rates due to Suicide and Homicide Among Persons Aged 10\u201324: United States, 2000\u20132017","author":"Curtin SC","year":"2019"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.20956"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019\u20103823"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6708a1"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.02.018"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/13811118.2012.667334"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.5820\/aian.2304.2016.86"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022146518814251"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2005.02.009"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/15374416.2014.910789"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpra.2011.01.001"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/sltb.12554"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.1776"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.2105\/ajph.2015.302656"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.6014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pon.6014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.6014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T13:39:40Z","timestamp":1699277980000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.6014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,27]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/pon.6014"],"URL":"https:\/\/doi.org\/10.1002\/pon.6014","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,27]]},"assertion":[{"value":"2022-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}