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The aim of this study is to analyse the association between depressive symptoms and CRC survival at 5\u00a0years after diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicentre, prospective, observational cohort study was conducted on a sample of 2602 patients with CRC who completed the Hospital Anxiety and Depression Scale (HADS\u2010D) at 5 years of follow\u2010up. Survival was analysed using the Kaplan\u2013Meier method and Cox regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to our analysis, the prevalence of depressive symptoms after a CRC diagnosis was 23.8%. The Cox regression analysis identified depression as an independent risk factor for survival (HR\u00a0=\u00a01.47; 95% CI: 1.21\u20131.8), a finding which persisted after adjusting for sex (female: HR\u00a0=\u00a00.63; 95% CI: 0.51\u20130.76), age (&gt;70\u00a0years: HR\u00a0=\u00a03.78; 95% CI: 1.94\u20137.36), need for help (yes: HR\u00a0=\u00a01.43; 95% CI: 1.17\u20131.74), provision of social assistance (yes: HR\u00a0=\u00a01.46; 95% CI: 1.16\u20131.82), tumour size (T3\u2013T4: HR\u00a0=\u00a01.56; 95% CI: 1.22\u20131.99), nodule staging (N1\u2013N2: HR\u00a0=\u00a02.46; 95% CI: 2.04\u20132.96), and diagnosis during a screening test (yes: HR\u00a0=\u00a00.71; 95% CI: 0.55\u20130.91).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a high prevalence of depressive symptoms in patients diagnosed with CRC. These symptoms were negatively associated with the survival rate independently of other clinical variables. Therefore, patients diagnosed with CRC should be screened for depressive symptoms to ensure appropriate treatment can be provided.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.6018","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T18:35:25Z","timestamp":1661106925000},"page":"1762-1773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Influence of depression on survival of colorectal cancer patients drawn from a large prospective cohort"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8952-0608","authenticated-orcid":false,"given":"Esperanza","family":"Varela\u2010Moreno","sequence":"first","affiliation":[{"name":"Research Unit Costa del Sol Health Agency  Marbella Spain"},{"name":"Health Services Research Network on Chronic Diseases\u2014REDISSEC  Valencia Spain"},{"name":"Biomedical Research Institute of M\u00e1laga (IBIMA)  M\u00e1laga 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