{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:06:31Z","timestamp":1787065591647,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Studies show significant co\u2010occurrence of bipolar disorder and prostate cancer, as well as the presence of shared genes associated with both diseases. Our aim was to evaluate whether prostate cancer patients present bipolar spectrum symptoms and to establish their possible associations with stress related symptoms during diagnosis and the course of the cancer therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>200 participants were enrolled to this study: 100 prostate cancer patients and 100 healthy males. Bipolar spectrum symptoms were measured with the use of Mood Disorder Questionnaire and Hypomania Checklist\u201032 (HCL\u201032). Stress related symptoms were rated with The Impact of Events Scale\u2010Revised (IES\u2010R), Perceived Stress Scale\u201010 (PSS\u201010) and Generalised Self\u2010Efficacy Scale (GSES).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In comparison to healthy controls group, prostate cancer patients have shown higher HCL\u201032 scores. Mood Disorder Questionnaire measures were associated with more severe stress related to prostate cancer diagnosis and treatment reflected by higher scores of IES\u2010R and its subscales (Avoidance, Intrusions and Hyperarousal). Mood Disorder Questionnaire, HCL\u201032, PSS\u201010, IES\u2010R and GSES measures were not associated with clinical characteristics of prostate cancer severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>Cross\u2010sectional study model precluded identification of causal relationship among variables. Bipolar spectrum symptoms and stress related measures were based on auto\u2010questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>To our best knowledge, this is the first study evaluating bipolar spectrum symptoms in prostate cancer patients. We have shown that this clinical group presents increased bipolarity traits compared to healthy individuals. Moreover, bipolar spectrum symptoms were associated with more severe stress related to the prostate cancer diagnosis and its treatment, reflected in avoidance, hyperarousal, and intrusions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.6096","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T23:40:10Z","timestamp":1673480410000},"page":"438-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bipolar spectrum in prostate cancer patients and its role in stress related symptoms"],"prefix":"10.1002","volume":"32","author":[{"given":"Adrian Andrzej","family":"Chrobak","sequence":"first","affiliation":[{"name":"Department of Adult Psychiatry Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miko\u0142aj","family":"Przydacz","sequence":"additional","affiliation":[{"name":"Department of Urology Jagiellonian University in Cracow  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Ch\u0142osta","sequence":"additional","affiliation":[{"name":"Department of Urology Jagiellonian University in Cracow  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Machalska","sequence":"additional","affiliation":[{"name":"Student's Scientific Association of Affective Disorders Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksander","family":"Turek","sequence":"additional","affiliation":[{"name":"Student's Scientific Association of Affective Disorders Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Popi\u00f3\u0142","sequence":"additional","affiliation":[{"name":"Student's Scientific Association of Affective Disorders Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Skalski","sequence":"additional","affiliation":[{"name":"Department of Adult Psychiatry Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Arciszewska\u2010Leszczuk","sequence":"additional","affiliation":[{"name":"Faculty of Psychology SWPS University of Social Sciences and Humanities  Sopot Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Ch\u0142osta","sequence":"additional","affiliation":[{"name":"Department of Urology Jagiellonian University in Cracow  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Siwek","sequence":"additional","affiliation":[{"name":"Department of Affective Disorders Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Dudek","sequence":"additional","affiliation":[{"name":"Department of Adult Psychiatry Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Lectures on Clinical Psychiatry","author":"Kraepelin E","year":"1917"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20105618.2007.00562.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.08.036"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.02.017"},{"key":"e_1_2_10_6_1","first-page":"99","article-title":"The emergence of the bipolar spectrum: validation along clinical\u2010epidemiologic and familial\u2010genetic lines","volume":"40","author":"Akiskal HS","year":"2007","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_10_7_1","volume-title":"Manic\u2010Depressive Illness","author":"Goodwin R","year":"2007"},{"key":"e_1_2_10_8_1","unstructured":"DisGeNET \u2010 a Database of Gene\u2010Disease Associations[Internet]. 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