{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:11:04Z","timestamp":1790111464754,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GP1407B"],"award-info":[{"award-number":["01GP1407B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Women carrying a\n                      <jats:italic>BRCA1\/2<\/jats:italic>\n                      pathogenic variant have an increased risk for breast cancer and may opt for risk\u2010reducing bilateral mastectomy. In this study, we examine which demographic, psychosocial, and personality factors are associated with their decision to undergo risk\u2010reducing bilateral mastectomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Cancer\u2010unaffected women with a pathogenic variant in\n                      <jats:italic>BRCA1<\/jats:italic>\n                      or\n                      <jats:italic>BRCA2<\/jats:italic>\n                      were recruited before receiving their genetic test result and completed follow\u2010up including decision to undergo mastectomy over 6\u20138\u00a0months after genetic test result disclosure. Anxiety, depression, breast cancer worry, personality and sociodemographic data were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 125 cancer\u2010unaffected women were included in the analysis. Participants were found to have higher anxiety levels than the general female population regardless of mastectomy decision. Breast cancer worry was higher among women who opted for risk\u2010reducing mastectomy and did not decrease over time. By contrast, women who did not opt for surgery experienced decreasing levels of breast cancer worry. Regression analysis found that women with a pathogenic variant in\n                      <jats:italic>BRCA1<\/jats:italic>\n                      , younger women and women with higher breast cancer worry were more likely to opt for surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our study provides valuable insights into the factors that influence women with a\n                      <jats:italic>BRCA1\/2<\/jats:italic>\n                      pathogenic variant to undergo risk\u2010reducing mastectomy. These findings may be helpful in understanding individual differences in decision\u2010making concerning preventive options and show the need to address negative anticipatory feelings associated with carrying a pathogenic variant in a high breast cancer risk gene in clinical care.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.6111","type":"journal-article","created":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T08:38:40Z","timestamp":1676191120000},"page":"640-648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Psychological distress and decision\u2010making factors for prophylactic bilateral mastectomy in cancer\u2010unaffected BRCA1\/2 pathogenic variant carriers"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5196-5716","authenticated-orcid":false,"given":"Anna","family":"Isselhard","sequence":"first","affiliation":[{"name":"Institute of Health Economics and Clinical Epidemiology University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-8397","authenticated-orcid":false,"given":"Anja","family":"T\u00fcchler","sequence":"additional","affiliation":[{"name":"Center for Hereditary Breast and Ovarian Cancer Center for Integrated Oncology (CIO), Medical Faculty University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Dick","sequence":"additional","affiliation":[{"name":"Center for Hereditary Breast and Ovarian Cancer Center for Integrated Oncology (CIO), Medical Faculty University Hospital Cologne  Cologne 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