{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:04:29Z","timestamp":1792271069173,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006244","name":"Stichting Kinderen Kankervrij","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006244","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe psychosocial outcomes among adult siblings of very long\u2010term childhood cancer survivors (CCS), to compare these outcomes to reference populations and to identify factors associated with siblings' psychosocial outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Siblings of survivors (diagnosed &lt;18\u00a0years old, between 1963 and 2001, &gt;5\u00a0years since diagnosis) of the Dutch Childhood Cancer Survivor Study DCCSS\u2010LATER cohort were invited to complete questionnaires on HRQoL (TNO\u2010AZL Questionnaire for Adult's HRQoL), anxiety\/depression (Hospital Anxiety and Depression Scale), post\u2010traumatic stress (Self\u2010Rating Scale for Post\u2010traumatic Stress Disorder), self\u2010esteem (Rosenberg Self\u2010Esteem Scale) and benefit and burden (Benefit and Burden Scale for Children). Outcomes were compared to a reference group if available, using Mann\u2010Whitney U and chi\u2010Square tests. Associations of siblings' sociodemographic and CCS\u2019 cancer\u2010related characteristics with the outcomes were assessed with mixed model analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five hundred five siblings (response rate 34%, 64% female, mean age 37.5, mean time since diagnosis 29.5) of 412 CCS participated. Siblings had comparable HRQoL, anxiety and self\u2010esteem to references with no or small differences (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.08\u22120.15, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) and less depression. Proportions of symptomatic PTSD were very small (0.4%\u22120.6%). Effect sizes of associations of siblings' sociodemographic and CCS cancer\u2010related characteristics were mostly small to medium (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.19\u22120.67, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) and no clear trend was found in the studied associated factors for worse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>On the very long\u2010term, siblings do not have impaired psychosocial functioning compared to references. Cancer\u2010related factors seem not to impact siblings' psychosocial functioning. Early support and education remain essential to prevent long\u2010term consequences.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.6191","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T04:21:37Z","timestamp":1689135697000},"page":"1401-1411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Psychosocial functioning of adult siblings of Dutch very long\u2010term survivors of childhood cancer: DCCSS\u2010LATER 2\u00a0psycho\u2010oncology study"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9797-0534","authenticated-orcid":false,"given":"Mala M. H.","family":"Joosten","sequence":"first","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1690-5926","authenticated-orcid":false,"given":"Marloes","family":"van Gorp","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leontien C. M.","family":"Kremer","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Department of Pediatrics Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"van Dulmen\u2010den Broeder","sequence":"additional","affiliation":[{"name":"Amsterdam UMC\/location VUmc  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim J. E.","family":"Tissing","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Beatrix Children's Hospital\/University of Groningen\/University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline J.","family":"Loonen","sequence":"additional","affiliation":[{"name":"Radboudumc Center of Expertise for Cancer Survivorship Department of Hematology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena J. H.","family":"van der Pal","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrica C. H.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Erasmus MC Sophia Children's Hospital\/Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marry M.","family":"van den Heuvel\u2010Eibrink","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Erasmus MC Sophia Children's Hospital\/Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Ronckers","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Department of Health Services Research Carl v Ossietzky University of Oldenburg  Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorine","family":"Bresters","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marloes","family":"Louwerens","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian J. 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