{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:28:17Z","timestamp":1791419297950,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Fear of Cancer Recurrence (FCR) is highly prevalent among cancer survivors and leads to decreased quality of life and increased healthcare costs. We assessed the effectiveness of a guided online primary care intervention for FCR, compared to waiting list.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this RCT, participants were recruited online and randomised 1:1. All adults who finished successful curative cancer treatment between 3\u00a0months and 10 years ago, wanted support for FCR, and had sufficient Dutch skills were eligible. The intervention consisted of a 10\u2010week online programme and three to five video calling sessions with a trained mental health worker. After 6\u00a0months, the control group received the same intervention. The primary outcome was the difference between the groups in the change in FCR severity from baseline (T0) to 6\u00a0months (T2), measured online with the short form of the Fear of Cancer Recurrence Inventory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and seventy\u2010three participants were enroled and randomised to the intervention (<jats:italic>n<\/jats:italic>\u00a0=\u00a086) or control group (<jats:italic>n<\/jats:italic>\u00a0=\u00a087). FCR severity dropped 2.1 points more in the intervention group than in the control group (2.7 points (SD\u00a0=\u00a03.9) versus 0.6 points (SD\u00a0=\u00a03.6), <jats:italic>t<\/jats:italic>(154)\u00a0=\u00a03.4, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0007). General mental well\u2010being also improved significantly in the intervention group and remained stable in the control group. These improvements remained at 10\u00a0months follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This easily accessible and relatively inexpensive intervention effectively reduces FCR and has potential to replace or precede existing more intensive psychological treatments, improving patients' access to care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p>The trial was prospectively registered in the Netherlands Trial Register on 25\u201002\u20102019 with number NL7573.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.6231","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T13:53:15Z","timestamp":1697637195000},"page":"1839-1847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effectiveness of a guided online primary care intervention for fear of cancer recurrence: A randomised controlled trial"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1611-3627","authenticated-orcid":false,"given":"Yvonne L.","family":"Luigjes\u2010Huizer","sequence":"first","affiliation":[{"name":"Helen Dowling Institute  Bilthoven The Netherlands"},{"name":"Julius Centre for Health Sciences and Primary Care University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3268-174X","authenticated-orcid":false,"given":"Charles W.","family":"Helsper","sequence":"additional","affiliation":[{"name":"Julius Centre for Health Sciences and Primary Care University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0273-8290","authenticated-orcid":false,"given":"Niek J.","family":"de Wit","sequence":"additional","affiliation":[{"name":"Julius Centre for Health Sciences and Primary Care 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