{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:12:49Z","timestamp":1790385169417,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T00:00:00Z","timestamp":1703894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Cancer predisposition syndromes are being more frequently recognized in the etiology of pediatric oncology and genetic\u2010related technologies are evolving rapidly, leading to an increasing availability of genetic testing for families. This systematic review assessed the psychological impact of genetic testing on children and parents in the context of childhood cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Searches were performed using three databases (Web of Science, Pubmed and Embase) to identify relevant empirical studies. Following Cochrane guidelines, we screened 3838 articles and identified 18 eligible studies, representing the perspectives of children and\/or parents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The included studies described the impact of genetic testing in different contexts (e.g. predictive testing and diagnostic testing) and in different subgroups, (e.g. carriers and non\u2010carriers). Overall, the studies did not identify clinically\u2010relevant long\u2010term increases in negative emotions (depression, anxiety, distress, uncertainty, guilt) as a result of genetic testing. Negative emotions were typically time\u2010limited and generally occurred in families with particular characteristics (e.g. those with a history of multiple cancer diagnoses, families receiving an unfavorable result for one child and a favorable result in siblings, and those with pre\u2010existing mental health difficulties). Positive emotions (hopefulness, relief and peace of mind) were also reported. Knowing their genetic risk status appeared to help to foster empowerment among families, regardless of the result and any associated emotions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Genetic testing in pediatric oncology does not appear to cause significant additional harm and can lead to positive outcomes. Clinicians need to be especially attentive when counseling families at increased risk of distress.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.6279","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T17:18:21Z","timestamp":1703956701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The psychological impact of genetic testing in childhood cancer: A systematic review"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2436-3669","authenticated-orcid":false,"given":"Sophie","family":"Van Hoyweghen","sequence":"first","affiliation":[{"name":"Department of Biomolecular Medicine Faculty of Medicine and Health Sciences University of Ghent  Ghent Belgium"},{"name":"Department of Experimental Clinical and Health Psychology Faculty of Psychology and Educational Sciences University of Ghent  Ghent Belgium"},{"name":"Cancer Research Institute Ghent CRIG  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0841-7372","authenticated-orcid":false,"given":"Kathleen","family":"BM Claes","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Medicine Faculty of Medicine and Health Sciences University of Ghent  Ghent Belgium"},{"name":"Cancer Research Institute Ghent CRIG  Ghent Belgium"},{"name":"Center of Medical Genetics Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9410-8941","authenticated-orcid":false,"given":"Robin","family":"de Putter","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Medicine Faculty of Medicine and Health Sciences University of Ghent  Ghent Belgium"},{"name":"Cancer Research Institute Ghent CRIG  Ghent Belgium"},{"name":"Center of Medical Genetics Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7704-7067","authenticated-orcid":false,"given":"Claire","family":"Wakefield","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine UNSW Medicine and Health UNSW Sydney  Sydney Australia"},{"name":"Behavioural Sciences Unit Kids Cancer Centre Sydney Children's Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2745-9914","authenticated-orcid":false,"given":"Marieke","family":"Van Schoors","sequence":"additional","affiliation":[{"name":"Familieplatform VZW  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Hellemans","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Medicine Faculty of Medicine and Health Sciences University of Ghent  Ghent Belgium"},{"name":"Center of Medical Genetics Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2767-5422","authenticated-orcid":false,"given":"Lesley","family":"Verhofstadt","sequence":"additional","affiliation":[{"name":"Department of Experimental Clinical and Health Psychology Faculty of Psychology and Educational Sciences University of Ghent  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010017\u20100077\u20108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25480"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27907"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.06.186"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2014.11.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2018.05.016"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(16)30249\u20102"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689\u2010010\u20109368\u2010z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.27.0660"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2006.06.6100"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010017\u20102997\u20106"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.181"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2018.38.4.291"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2023\u2010061832"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.05.022"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpdn.2000.8044"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1043\u20104542(96)90090\u20109"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0738\u20103991(97)00063\u20103"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.06.005"},{"key":"e_1_2_9_21_1","unstructured":"HigginsJPT ThomasJ ChandlerJ et\u00a0al.Cochrane Handbook for Systematic Reviews of Interventions Version 6.3;2022.http:\/\/www.training.cochrane.org\/handbook"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/25.6.449"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1638"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1996.02170360021003"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.10926"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20100004.2010.01534.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010017\u20100185\u20105"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096\u20108628(20001002)94:4<316::aid\u2010ajmg10>3.0.co;2\u2010n"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27762"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.8.519"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-017-0027-9"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-017-0091-x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6016"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30158"},{"key":"e_1_2_9_35_1","article-title":"Parental perspectives on whole exome sequencing in pediatric cancer: a typology of perceived utility","volume":"1","author":"Malek J","year":"2017","journal-title":"JCO Precis Oncol"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-019-0570-6"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/07347332.2020.1768199"},{"key":"e_1_2_9_38_1","article-title":"Perspectives and experiences of parents and adolescents who participate in a pediatric precision oncology program: \"when you feel helpless, this kind of thing is very helpful","volume":"6","author":"Waldman L","year":"2022","journal-title":"JCO Precis Oncol"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27445"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/tbm\/ibx011"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689\u2010014\u20109724\u20105"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0014778"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12868"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278\u20106133.21.6.564"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100040\u20101721439"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14971"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051365"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326\u20105377.2003.tb05069.x"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.2080"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1687"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33357"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28879"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010015\u20109912\u2010y"},{"key":"e_1_2_9_54_1","volume-title":"Social Learning Theory","author":"Bandura A","year":"1977"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsu034"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl069"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.6279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T08:36:52Z","timestamp":1707381412000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.6279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,30]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/pon.6279"],"URL":"https:\/\/doi.org\/10.1002\/pon.6279","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,30]]},"assertion":[{"value":"2023-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6279"}}