{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T08:32:34Z","timestamp":1789288354930,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Non\u2010adherence to adjuvant endocrine therapy (AET) in women with breast cancer is common and associated with medication side\u2010effects and distress. We co\u2010designed an <jats:styled-content>A<\/jats:styled-content>cceptance and <jats:styled-content>C<\/jats:styled-content>ommitment <jats:styled-content>T<\/jats:styled-content>herapy intervent<jats:styled-content>ion<\/jats:styled-content> (ACTION) to enhance medication decision\u2010making and quality of life (QoL). We undertook a pilot trial of ACTION to inform the feasibility of a phase III trial, and to examine intervention acceptability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multi\u2010site, exploratory, two\u2010arm, individually randomised external pilot trial. Women with early breast cancer prescribed AET were randomised (1:1) to receive usual care (UC) or UC\u00a0+\u00a0ACTION. The ACTION intervention comprised a remotely delivered one\u2010to\u2010one ACT session followed by three group sessions delivered by clinical psychologists, alongside a website containing ideas for the self\u2010management of side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 480 women screened for eligibility, 260 (54.2%) were approached and 79 (30.4%) randomised. 71 (89.9%) women provided data at 3\u2010month and 70 (88.6%) at 6\u2010month 40 women were randomised to receive UC\u00a0+\u00a0ACTION and 32 (80.0%) completed the intervention. Most (75.0%) accessed the website at least once. ACTION was acceptable to participants (Borkovec &amp; Nau Scale: mean\u00a0=\u00a07.8 [SD\u00a0=\u00a02.7] out of 10). Signals of effectiveness in favour of the UC\u00a0+\u00a0ACTION arm were observed for medication adherence (Adherence Starts with Knowledge questionnaire\u201012), QoL (work and social adjustment scale), health\u2010related QoL (functional assessment of cancer therapy[FACT] general and FACT\u2010ES\u201019\/23), distress (generalised anxiety disorder \u20107, patient health questionnaire\u20109) and psychological flexibility (valuing questionnaire).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The ACTION intervention was acceptable to patients. There were promising signals for effectiveness on primary and secondary outcomes. A phase III randomised controlled trial is feasible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>ISRCTN12027752.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.6349","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T13:08:15Z","timestamp":1715864895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A pilot randomised controlled trial of acceptance and commitment therapy for medication decision\u2010making and quality of life in women with breast cancer: The ACTION trial"],"prefix":"10.1002","volume":"33","author":[{"given":"Christopher D.","family":"Graham","sequence":"first","affiliation":[{"name":"Department of Psychological Sciences and Health University of Strathclyde  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Ellison","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9032-4540","authenticated-orcid":false,"given":"Louise H.","family":"Hall","sequence":"additional","affiliation":[{"name":"Leeds Institute of Health Science University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology St James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"McNaught","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit Leeds Institute of Clinical Trials Research University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie M. 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