{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:20:45Z","timestamp":1792167645351,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008750","name":"Shanghai Municipal Hospital Development Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Influenced by their life stage and socio\u2010cultural background, young and middle\u2010aged cancer patients in China may experience unique psychological distress. Therefore, this study investigated the severity, problems, and associated factors of psychological distress among young and middle\u2010aged cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional study on young and middle\u2010aged cancer patients aged 18\u201359 who were treated at a radiotherapy center from February 2022 to September 2023. Participants' psychological distress severity and problems were measured using the Distress Thermometer and the Problem List. Binary logistic regression was used to identify sociodemographic and clinical factors, as well as PL items, associated with clinically significant psychological distress in young and middle\u2010aged cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 510 participants, 102 (20.0%) had DT scores \u2265\u00a04, reported an average of 3.36\u00a0\u00b1\u00a03.78 problems, and 360 (70.6%) reported at least one problem. The five most frequently reported problems were worry, no time and energy to take care of children\/elderly people, memory loss\/lack of concentration, appearance\/shape, and work\/school. Annual household income, self\u2010reported loneliness, nervousness, loss of interest in daily activities, eating, and nausea were associated with DT scores \u2265\u00a04.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>One\u2010fifth of young and middle\u2010aged cancer patients experienced clinically significant psychological distress. Greater attention should be paid to patients with lower household incomes and those who self\u2010report loneliness, nervousness, loss of interest in daily activities, eating, and nausea, providing targeted support to alleviate psychological distress.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.70062","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T04:40:58Z","timestamp":1736484058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Psychological Distress and Problems Among Young and Middle\u2010Aged Cancer Patients Undergoing Treatment in China"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9520-7722","authenticated-orcid":false,"given":"Shuman","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nursing Shanghai Proton and Heavy Ion Center Fudan University Cancer Hospital  Shanghai China"},{"name":"Shanghai Key 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