{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:30:53Z","timestamp":1788820253199,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Cognitive\u2010behavioral intervention (CBI) has shown positive effects in improving psychological and health\u2010related outcomes in children with cancer. However, no evidence has been found in Ethiopia. This study aimed to evaluate the effects of CBI on anxiety, depression and quality of life (QoL) in Ethiopian children with hematological cancer receiving chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A parallel, two\u2010armed, assessor\u2010blinded, randomized controlled trial was conducted among 76 children randomized (1:1) to receive CBI or usual medical care. The intervention group received five weekly face\u2010to\u2010face CBI sessions of 30\u201340\u00a0min each, which included an introduction to CBI; identifying and challenging maladaptive thoughts, beliefs and behavior; behavior activation; deep breathing exercises; and treatment evaluation and relapse prevention. The outcomes were measured at baseline (T0), immediately post\u2010intervention (T1) and 1\u00a0month post\u2010intervention (T2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The intervention group showed a significant reduction in anxiety scores from T0 at T1 (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22126.67, 95% CI [\u22129.16, \u22124.19],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and T2 (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22128.14, 95% CI [\u221210.70, \u22125.57],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), depression at T1 (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22124.09, 95% CI [\u22126.94, \u22121.23],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005) and T2 (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22126.12, 95% CI [\u22129.10, \u22123.13],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and improvement in QoL at T2 (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a03.02, 95% CI [0.49, 5.56],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.019) compared with the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CBI has positive effects in reducing anxiety and depression and in improving QoL in children with hematological cancer receiving chemotherapy. The results suggest the need to incorporate CBI into pediatric hematology\u2010oncology and studies on its long\u2010term effects and cost\u2010effectiveness are warranted.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      (NCT05270655). Registered on 08 March 2022.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70086","type":"journal-article","created":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T23:00:31Z","timestamp":1737327631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cognitive\u2010Behavioral Intervention for Children With Hematological Cancer Receiving Chemotherapy: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"34","author":[{"given":"Tenaw Gualu","family":"Melesse","sequence":"first","affiliation":[{"name":"The Nethersole School of Nursing Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"},{"name":"Department of Pediatrics and Child Health Nursing College of Medicine and Health Sciences Debre Markos University  Debre Markos Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2562-769X","authenticated-orcid":false,"given":"William Ho Cheung","family":"Li","sequence":"additional","affiliation":[{"name":"The Nethersole School of Nursing Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janita Pak Chun","family":"Chau","sequence":"additional","affiliation":[{"name":"The Nethersole School of Nursing Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mulugeta Ayalew","family":"Yimer","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\u2010Oncology Unit Department of Pediatrics and Child Health School of Medicine College of Medicine and Health Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulkadir Mohamedsaid","family":"Gidey","sequence":"additional","affiliation":[{"name":"Pediatrics Hematology\u2010Oncology Division Department of Paediatrics and Child Health College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sewbesew","family":"Yitayih","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine College of Medicine and Health Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(19)30339\u20100"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(17)30186\u20109"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JGO.17.00175"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104\u2010015\u20101440\u20101"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0b013e3181aaf0fa"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359104518788400"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454219849578"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1188\/19.ONF.228\u2010237"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5610"},{"key":"e_1_2_10_11_1","first-page":"105","volume-title":"Pediatric Psycho\u2010Oncology: A Quick Reference on the Psychosocial Dimensions of Cancer Symptom Management","author":"Pao M.","year":"2015"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20107610.2011.02446.x"},{"issue":"1","key":"e_1_2_10_13_1","first-page":"113","article-title":"Emotional and Behavioral Disorders in Pediatric Cancer Patients","volume":"14","author":"Zahed G.","year":"2020","journal-title":"Iranian Journal of Child Neurology"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17103563"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4100"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/27527530211056001"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0b013e318250da1a"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chc.2010.01.009"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201040698\u20100"},{"key":"e_1_2_10_20_1","first-page":"101","volume-title":"Depression and Cancer","author":"DiMatteo M. 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