{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:06:07Z","timestamp":1784865967166,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K09966"],"award-info":[{"award-number":["JP23K09966"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Patients with relapsed or refractory (r\/r) indolent non\u2010Hodgkin lymphoma (iNHL) live with incurable disease for a long\u2010term, experiencing multiple relapses and treatments that impair their health\u2010related quality of life (HRQOL). We aimed to better understand the unmet needs and HRQOL of patients with r\/r iNHL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This convergent mixed\u2010methods study evaluated patients with r\/r iNHL who received treatment. Unmet needs and HRQOL were assessed quantitatively using self\u2010administered questionnaires and analyzed statistically. Qualitative data were collected through face\u2010to\u2010face semi\u2010structured interviews for reflexive thematic analysis. Quantitative and qualitative findings were integrated through narrative discussion and joint display.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Questionnaire respondents (50 participants, mean age: 72.42\u00a0years) reported unmet needs in the health system and information and psychological domains and a negative association between unmet needs and HRQOL. Interviews (20 participants, mean age: 72.75\u00a0years) identified four themes: \u201cunremarkable symptoms,\u201d \u201canxiety of progression in the near future,\u201d \u201cmake the best of life,\u201d and \u201cmeans to live with uncertainty.\u201d Integration revealed that participants accepted their low HRQOL and attempted to make the best of life, influencing their perception of unmet needs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Throughout the long course of r\/r and repeated treatment, patients with iNHL accepted their low HRQOL, valued their current situations, and endeavored to make the best of life. In this situation, support in the psychological and health system and information domains is crucial. Support for the unmet needs of patients with r\/r iNHL is essential as they strive to live their best lives while maintaining a favorable HRQOL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.70103","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T05:28:36Z","timestamp":1738906116000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Unmet Needs and Health\u2010Related Quality of Life Among Patients With Relapsed\/Refractory Indolent Non\u2010Hodgkin Lymphoma: A Mixed\u2010Methods Study"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2008-7592","authenticated-orcid":false,"given":"Miki","family":"Sugimoto","sequence":"first","affiliation":[{"name":"Graduate School of Health Management Keio University  Tokyo Japan"},{"name":"Faculty of Nursing and Medical care Keio University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Yagasaki","sequence":"additional","affiliation":[{"name":"Faculty of Nursing and Medical care Keio University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Matsuki","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Keio University School of Medicine  Tokyo Japan"},{"name":"Division of Hematology Department of Medicine National Hospital Organization Tokyo Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Keio University School of Medicine  Tokyo Japan"},{"name":"Division of Molecular Oncology National Cancer Center Research Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardith Z.","family":"Doorenbos","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing Science College of Nursing University of Illinois Chicago  Chicago Illinois USA"},{"name":"Cancer Prevention and Control University of Illinois Cancer Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16489"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010020\u201000340\u2010z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26737"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27058"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010023\u201010546\u20106"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010024\u201002882\u20101"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm543"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010021\u201004470\u20107"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2020.09.002"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010023\u201000853\u20103"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010009\u20100615\u20105"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4136"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5973"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2017.03.002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913\u2010020\u201005927\u20107"},{"key":"e_1_2_9_18_1","unstructured":"United Nations Department of Economic and Social Affairs Population Division World Population Ageing 2019 accessed January 10 2025 https:\/\/digitallibrary.un.org\/record\/3907988\/files\/WorldPopulationAgeing2019\u2010Report.pdf."},{"key":"e_1_2_9_19_1","volume-title":"Designing and Conducting Mixed Methods Research","author":"Creswell J. 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