{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:32:14Z","timestamp":1767137534773,"version":"build-2238731810"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["856001005"],"award-info":[{"award-number":["856001005"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence on the efficacy of psychological interventions targeting cancer patients diagnosed with an adjustment disorder is scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to investigate the efficacy and budget impact of a tailored psychological intervention program (AD\u2010program) targeting cancer patients with adjustment disorder (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a059) were randomised to the intervention or control group. The AD\u2010program consisted of three modules: psychoeducation (1\u20134 sessions) and two additional modules (maximum of 6 sessions per module) provided when needed. The primary outcome was psychological distress (HADS). Secondary outcomes were mental adjustment to cancer (MAC) and health\u2010related quality of life (EORTC QLQ\u2010C30). Measures were completed at baseline and 3 and 6\u00a0months after randomisation. The budget impact analyses were based on the population size, the costs of the AD\u2010program, and other costs potentially affected by the AD\u2010program.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean psychological distress score in the intervention group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a033) decreased over time (\n                      <jats:italic>M<\/jats:italic>\n                      \u00a0=\u00a019.2 at T0,\n                      <jats:italic>M<\/jats:italic>\n                      \u00a0=\u00a015.6 at T6). This decrease was not significantly different from decrease in the control condition (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a026,\n                      <jats:italic>M<\/jats:italic>\n                      \u00a0=\u00a017.5 at T0,\n                      <jats:italic>M<\/jats:italic>\n                      \u00a0=\u00a015.9 at T6,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a00.05). Also, there were no significant differences between the two conditions on the secondary outcomes. The budget impact of the AD\u2010program was estimated at 7\u201328 million euros per year (to treat 14,430 patients).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The effect of the AD\u2010program was not statistically significant in this RCT. Limitations include that this study was underpowered due to recruitment difficulties during the COVID\u201019 pandemic. More research on the efficacy and implementation of the AD\u2010program is warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Netherlands Trial Register identifier: NL7763. Registered on 3 June 2019<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70123","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T09:57:06Z","timestamp":1742032626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Budget Impact of a Tailored Psychological Intervention Program Targeting Cancer Patients With Adjustment Disorder: A Randomised Controlled Trial"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1067-3327","authenticated-orcid":false,"given":"K.","family":"Holtmaat","sequence":"first","affiliation":[{"name":"Department of Clinical, Neuro and Developmental Psychology Vrije Universiteit Amsterdam  Amsterdam the Netherlands"},{"name":"Treatment and Quality of Life Cancer Center Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Public Health, Mental Health  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. E.","family":"van Beek","sequence":"additional","affiliation":[{"name":"Department of Clinical, Neuro and Developmental Psychology Vrije Universiteit Amsterdam  Amsterdam the Netherlands"},{"name":"Treatment and Quality of Life Cancer Center Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Public Health, Mental Health  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4234-4704","authenticated-orcid":false,"given":"L. M. A.","family":"Wijnhoven","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology Research Institute for Medical Innovation Radboudumc Nijmegen  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1573-6040","authenticated-orcid":false,"given":"J. A. E.","family":"Custers","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology Research Institute for Medical Innovation Radboudumc Nijmegen  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. J.","family":"Aukema","sequence":"additional","affiliation":[{"name":"Centre for Psycho\u2010Oncology Ingeborg Douwes Centrum  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. E. J.","family":"Eerenstein","sequence":"additional","affiliation":[{"name":"Treatment and Quality of Life Cancer Center Amsterdam  Amsterdam the Netherlands"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Amsterdam UMC Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. M.","family":"van Oort","sequence":"additional","affiliation":[{"name":"Department of Urology Radboudumc Nijmegen  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E. M.","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Surgery Oncology Radboudumc Nijmegen  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Wegdam","sequence":"additional","affiliation":[{"name":"Department of Surgery Elkerliek Hospital  Helmond the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. L. E.","family":"Jansen\u2010Engelen","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Jans Gasthuis Hospital  Weert the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. H. J. T.","family":"de Hingh","sequence":"additional","affiliation":[{"name":"Department of Surgery Catharina Hospital  Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Verheul","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology CWZ Nijmegen  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. T.","family":"van der Beek","sequence":"additional","affiliation":[{"name":"Department of Psychology and Psychiatry Haga Hospital  The Hague the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Wekking","sequence":"additional","affiliation":[{"name":"Psychologists Practice Wekking  Harderwijk the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Steggerda","sequence":"additional","affiliation":[{"name":"Bloem Psychology  Voorburg the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. M. H.","family":"Coup\u00e9","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Data Science Amsterdam UMC Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Horevoorts","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Psychology Tilburg University  Tilburg the Netherlands"},{"name":"The Netherlands Comprehensive Cancer Organization  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9201-9176","authenticated-orcid":false,"given":"A. M.","family":"de Korte","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Psychology Tilburg University  Tilburg the Netherlands"},{"name":"The Netherlands Comprehensive Cancer Organization  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lammens","sequence":"additional","affiliation":[{"name":"The Netherlands Comprehensive Cancer Organization  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. I.","family":"Lissenberg\u2010Witte","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Data Science Amsterdam UMC Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0172-0857","authenticated-orcid":false,"given":"B. H.","family":"de Rooij","sequence":"additional","affiliation":[{"name":"The Netherlands Comprehensive Cancer Organization  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5720-6091","authenticated-orcid":false,"given":"J. B.","family":"Prins","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology Research Institute for Medical Innovation Radboudumc Nijmegen  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. M.","family":"Verdonck\u2010de Leeuw","sequence":"additional","affiliation":[{"name":"Department of Clinical, Neuro and Developmental Psychology Vrije Universiteit Amsterdam  Amsterdam the Netherlands"},{"name":"Treatment and Quality of Life Cancer Center Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Public Health, Mental Health  Amsterdam the Netherlands"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Amsterdam UMC Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Treatment and Quality of Life Cancer Center Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Public Health, Mental Health  Amsterdam the Netherlands"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Amsterdam UMC Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_2_11_3_1","unstructured":"T.Vos M.Appelo T.Brouwer et\u00a0al. \u201cRichtlijn aanpassingsstoornis bij pati\u00ebnten met kanker \u201d Published online (2016)."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127\u2010021\u201002138\u20101"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010021\u201006530\u20100"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.36469\/jheor.2023.70238"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2023.111214"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4099"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6082"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6046"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010022\u201007337\u20103"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2022.01.005"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905\u2010023\u201002486\u2010x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2023.111366"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2023.104447"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jan.15543"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2022.151354"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6110"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/2347\u20105625.182930"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5673"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/OR9.0000000000000127"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40359\u2010019\u20100368\u2010y"},{"key":"e_1_2_11_23_1","article-title":"Behandeling voor een aanpassingsstoornis na somatische ziekte: Resultaten van een landelijke studie bij mensen die leven met de gevolgen van kanker","volume":"167","author":"Atema V.","year":"2023","journal-title":"Nederlands Tijdschrift voor Geneeskunde"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12880"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijchp.2022.100315"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1628"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.11.023"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2013.08.2291"},{"key":"e_1_2_11_29_1","unstructured":"Netherlands Cancer Registry (NCR) \u201cNetherlands Comprehensive Cancer Organisation (IKNL).\u201d"},{"key":"e_1_2_11_30_1","unstructured":"ZonMw \u201cBudget Impact Analyses in de praktijk: Leidraad en rekentool \u201d Published online (2020)."},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/07347332.2018.1519626"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5753"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.11.010"},{"key":"e_1_2_11_34_1","unstructured":"Cancer \u2010 Healthcare Expenditure. Dutch Government. (2023) https:\/\/www.vzinfo.nl\/kanker\/zorguitgaven#:~:text=Zorguitgavenkankerietshogervoorvrouwen&text=Deuitgavenvandezorg kanker6%2C5miljardeuro."}],"updated-by":[{"DOI":"10.1002\/pon.70153","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T00:00:00Z","timestamp":1744502400000}}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.70123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T12:27:55Z","timestamp":1743251275000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.70123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/pon.70123"],"URL":"https:\/\/doi.org\/10.1002\/pon.70123","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70123"}}