{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:12:23Z","timestamp":1789182743430,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T00:00:00Z","timestamp":1746316800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Patients with cancer have a high risk of suicide. However, evidence\u2010based preventive measures remain unclear. This study aimed to investigate suicide prevention strategies for hospitalized patients with cancer by analyzing nationwide patient safety reports using large language models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were drawn from patient safety reports collected by the Japan Council for Quality Health Care from 620 hospitals. Reports involving suicides or attempts among patients with cancer were analyzed. BERTopic was used to identify topics in free\u2010text reports, and conditions such as depressive symptoms were labeled using the OpenAI API. Logistic regression was conducted to analyze the relationship between pre\u2010incident conditions and proposed countermeasures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 213 reports, key topics included mental and physical distress, symptom deterioration, nursing records, and post\u2010incident documentation. Over 40% of patients exhibited depressive symptoms, and 30% expressed suicidal ideation. However, fewer received specialized mental care. Notably, over 10% appeared to experience delirium, potentially contributing to the incident. The most frequently suggested countermeasures were mental distress treatment, enhanced medical staff communication, and improved information sharing with families. Logistic regression revealed several associations between proposed countermeasures and pre\u2010incident conditions, including mental health intervention for patients without prior treatment, physical interventions for those in severe pain, and improved staff communication for those with depressive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study, based on nationwide patient safety reports, highlights critical suicide prevention strategies for hospitalized patients with cancer, many of which align with previously proposed strategies. Additionally, the study provides new insights, such as the need for preventive measures to manage delirium.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.70150","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T04:08:04Z","timestamp":1746418084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploratory Analysis of Nationwide Japanese Patient Safety Reports on Suicide and Suicide Attempts Among Inpatients With Cancer Using Large Language Models"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-8987","authenticated-orcid":false,"given":"Ken","family":"Kurisu","sequence":"first","affiliation":[{"name":"Department of Cancer Survivorship and Digital Medicine Jikei University School of Medicine  Tokyo Japan"},{"name":"Division of Survivorship Research National Cancer Center Institute for Cancer Control  Tokyo Japan"},{"name":"Department of Stress Sciences and Psychosomatic Medicine Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1639-3390","authenticated-orcid":false,"given":"Maiko","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Division of Survivorship Research National Cancer Center Institute for Cancer Control  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Harashima","sequence":"additional","affiliation":[{"name":"Division of Survivorship Research National Cancer Center Institute for Cancer Control  Tokyo Japan"},{"name":"Department of Stress Sciences and Psychosomatic Medicine Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Okamura","sequence":"additional","affiliation":[{"name":"Division of Survivorship Research National Cancer Center Institute for Cancer Control  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Yoshiuchi","sequence":"additional","affiliation":[{"name":"Department of Stress Sciences and Psychosomatic Medicine Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Uchitomi","sequence":"additional","affiliation":[{"name":"Department of Cancer Survivorship and Digital Medicine Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201001745\u2010y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5122"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6574"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyx003"},{"key":"e_1_2_9_6_1","volume-title":"Guide for Suicide Countermeasures in Oncology","author":"National Cancer Center Japan","year":"2020"},{"key":"e_1_2_9_7_1","unstructured":"\u201cDevelopment of Designated Cancer Care Hospitals and Related Facilities\u201d [in Japanese] accessed September 1 2024 https:\/\/www.mhlw.go.jp\/content\/000972176.pdf."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2019.07.003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u2010244X\u201011\u201038"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1553\u20107250(08)34060\u20104"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.01.076"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4815"},{"key":"e_1_2_9_13_1","unstructured":"\u201cJapan Council for Quality Health Care \u201d accessed September 1 2024 https:\/\/www.med\u2010safe.jp."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.104018"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2024.01.033"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.231362"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2024.111458"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.232741"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjhci\u20102023\u2010100924"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201082192\u20102"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ejihpe15010009"},{"key":"e_1_2_9_22_1","unstructured":"M.Grootendorst \u201cBERTopic: Neural Topic Modeling With a Class\u2010Based TF\u2010IDF Procedure \u201d Preprint arXiv (March 11 2022) https:\/\/doi.org\/10.48550\/arXiv.2203.05794."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010022\u201012926\u20102"},{"key":"e_1_2_9_24_1","unstructured":"Open AI \u201cAPI \u201d accessed September 1 2024 https:\/\/platform.openai.com\/docs\/overview."},{"key":"e_1_2_9_25_1","volume-title":"Approaches to Suicide Prevention in Hospitals","year":"2023"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2282011860"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31675"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(11)70002\u2010X"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.4.1594"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/10398562211064221"},{"key":"e_1_2_9_31_1","unstructured":"World Bank \u201cPopulation Ages 65 and Above (% of Total Population) \u201d accessed September 1 2024 https:\/\/data.worldbank.org\/indicator\/SP.POP.65UP.TO.ZS."},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010019\u20101571\u2010z"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440\u20101819.1999.00607.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyad042"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.20.2467"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951511000599"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951521001565"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(14)70259\u20107"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hys188"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.2023.J081"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.70150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T14:43:18Z","timestamp":1748356998000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.70150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/pon.70150"],"URL":"https:\/\/doi.org\/10.1002\/pon.70150","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70150"}}