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Participants receiving immediate treatment also experienced greater reductions in depression (<jats:italic>M<\/jats:italic><jats:sub>diff<\/jats:sub>\u00a0=\u00a0\u22124.22, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and improvements in coping abilities (<jats:italic>M<\/jats:italic><jats:sub>diff<\/jats:sub>\u00a0=\u00a00.36, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and optimism (<jats:italic>M<\/jats:italic><jats:sub>diff<\/jats:sub>\u00a0=\u00a01.39, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02), with no significantly different changes in mindfulness (<jats:italic>M<\/jats:italic><jats:sub>diff<\/jats:sub>\u00a0=\u00a04.36, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.14), anxiety (<jats:italic>M<\/jats:italic><jats:sub>diff<\/jats:sub>\u00a0=\u00a0\u22121.23, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.26), gratitude (<jats:italic>M<\/jats:italic><jats:sub>diff<\/jats:sub>\u00a0=\u00a00.59, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.47), or NF\u2010\u03baB activity (<jats:italic>M<\/jats:italic><jats:sub>diff<\/jats:sub>\u00a0=\u00a0\u22120.16, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.23).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The SMART\u20103RP demonstrated efficacy for global distress and other important outcomes for individuals with MGUS and SMM. Stress reduction did not significantly differ from waitlist control.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p><jats:bold>Trial Registration:<\/jats:bold> ClinicalTrials.gov Registration #: NCT01955395<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.70216","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T03:18:47Z","timestamp":1752895127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Psychosocial and NF\u2010\u03baB Activity Effects of the Stress Management and Resiliency Training: Relaxation Response Resiliency Program (SMART\u20103RP) on Patients With MGUS and Smoldering Multiple Myeloma: A Randomized Waitlist Control Trial"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7799-9164","authenticated-orcid":false,"given":"Lucy","family":"Finkelstein\u2010Fox","sequence":"first","affiliation":[{"name":"Health Promotion and 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