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Consequently, attention to palliative care for AYAs with cancer has just started, and our understanding of palliative care for AYA oncology remains limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aims to update our understanding of this salient topic through rigorous research synthesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A systematic review of empirical literature was adopted, and data was innovatively analyzed using meta\u2010thematic analysis. The review was pre\u2010registered on OSF (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/osf.io\/zy9cs\">https:\/\/osf.io\/zy9cs<\/jats:ext-link>). Studies were searched across ten electronic databases from inception to August 1, 2024 (i.e., the search date). Eligibility criteria include: (1) study the topic of palliative care; (2) focus on AYA cancer; and (3) report empirical data. Meta\u2010thematic analysis and reflexive thematic analysis informed data analysis methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010six primary studies from 2004 to 2024, inclusive of 478 data points, were included in the meta\u2010thematic analysis. Five broad themes were identified: (1) the overall state of AYA palliative care; (2) key characteristics of palliative care for AYAs with cancer; (3) AYA palliative care communication, decision\u2010making, and AYA involvement; (4) prevalent symptoms, care preferences, and priorities in palliative care among AYAs with cancer; and (5) effective interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Key insights regarding AYA cancer palliative care have been revealed. Notable areas of improvement regarding the delivery of palliative care to AYAs and future research directions have been identified.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.70228","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T05:09:02Z","timestamp":1752556142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Current State of Palliative Care Research for Adolescents and Young Adults With Cancer: A Systematic Review and Meta\u2010Thematic Analysis of Empirical Literature"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3199-1113","authenticated-orcid":false,"given":"Anao","family":"Zhang","sequence":"first","affiliation":[{"name":"University of Michigan School of Social Work Michigan Medicine AYA Oncology Program  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1283-5961","authenticated-orcid":false,"given":"Meiyan","family":"Chen","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin School of Social Work  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Brandon","sequence":"additional","affiliation":[{"name":"University of Michigan School of Social Work and Department of Psychology  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Currin\u2010McCulloch","sequence":"additional","affiliation":[{"name":"Colorado State University School of Social Work  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Michigan Medicine AYA Oncology Program  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brennan","family":"Cheladyn","sequence":"additional","affiliation":[{"name":"Michigan Medicine AYA Oncology Program  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Ferrell","sequence":"additional","affiliation":[{"name":"City of Hope Medical Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Jones","sequence":"additional","affiliation":[{"name":"Boston University School of Social Work  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Zebrack","sequence":"additional","affiliation":[{"name":"University of Michigan School of Social Work Michigan Medicine AYA Oncology Program  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9163-8792","authenticated-orcid":false,"given":"Adam S.","family":"DuVall","sequence":"additional","affiliation":[{"name":"Department of Medicine Assistant Professor of Medicine and Assistant Professor of Pediatrics University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21585"},{"key":"e_1_2_11_3_1","article-title":"Prevalence of Cancer Survivors Diagnosed During Adolescence and Young Adulthood in the United States","author":"Page L. 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