{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:54:15Z","timestamp":1775807655341,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The clinical trial landscape in oncology has evolved, with shifting endpoints and increased emphasis on early\u2010phase clinical trials (EPCTs) across European centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to update knowledge on the experiences of patients enrolling in EPCTs, focusing on the individual\/contextual factors influencing decision\u2010making, and how to improve ethical and psycho\u2010oncological support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This qualitative single\u2010center study was part of a broader multicenter project. Twenty\u2010five patients with locally advanced or metastatic solid cancer, for whom standard therapies had failed, were interviewed face\u2010to\u2010face, at a French EPCT center. A reflexive thematic analysis of the transcripts was conducted, following Braun and Clarke's six\u2010step approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four overarching themes emerged: \u201cExperiencing the EPCT proposal\u201d, \u201cAccepting the EPCT\u201d, \u201cAmbivalent feelings\u201d and \u201cCoping strategies\u201d, and several subthemes. Decisions were often made quickly in crisis situations and perceived as the only option. While patients reported receiving adequate information, their understanding of the trial's aims varied. Emotional distress and time pressure likely hindered full comprehension. Patients relied on trust in clinicians and reframed trial participation as a constructive goal, drawing on coping strategies to manage uncertainty and restore a sense of coherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients were neither delusional nor misinformed, but their decisions were shaped by complex emotional and relational dynamics. The perception of being well informed does not ensure true understanding, especially in high\u2010stress contexts. Ambivalent emotions, tensions between expectations and hopes, and constrained choices should be considered when tailoring supportive care. Evidence\u2010based strategies are needed to enhance communication and shared decision\u2010making in EPCT settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70291","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T02:39:21Z","timestamp":1759459161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Accepting to Participate in an Early\u2010Phase Clinical Trial in Oncology: A Qualitative Study on the Patients' Experiences, Understanding, and Inner Motivations"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9608-0791","authenticated-orcid":false,"given":"Estelle","family":"Guerdoux","sequence":"first","affiliation":[{"name":"Department of Palliative and Supportive Care Montpellier Cancer Institute University of Montpellier  Montpellier France"},{"name":"Desbrest Institute of Epidemiology and Public Health INSERM University of Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8143-7997","authenticated-orcid":false,"given":"Anne","family":"Stoebner","sequence":"additional","affiliation":[{"name":"Department of Palliative and Supportive Care Montpellier Cancer Institute University of Montpellier  Montpellier France"},{"name":"Desbrest Institute of Epidemiology and Public Health INSERM University of Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2567-0667","authenticated-orcid":false,"given":"Louise","family":"Coutant","sequence":"additional","affiliation":[{"name":"Department of Palliative and Supportive Care Montpellier Cancer Institute University of Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Zamith\u2010Chavant","sequence":"additional","affiliation":[{"name":"Department of Supportive Care Toulouse Cancer University Institute \u2010 Oncopole  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4363-2502","authenticated-orcid":false,"given":"Sylvie","family":"Dolbeault","sequence":"additional","affiliation":[{"name":"Department of Supportive Care Curie Institute  Paris France"},{"name":"SHARE PSL University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3905-0076","authenticated-orcid":false,"given":"Jessica","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Early Clinical Trial Unit Montpellier Cancer Institute University of Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5156-7395","authenticated-orcid":false,"given":"Marta","family":"Jarlier","sequence":"additional","affiliation":[{"name":"Biometrics Unit Montpellier Cancer Institute University of Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0401-7400","authenticated-orcid":false,"given":"Diego","family":"Tosi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Early Clinical Trial Unit Montpellier Cancer Institute University of Montpellier  Montpellier France"},{"name":"Fondazione Gianni Bonadonna  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010022\u201006306\u20109"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/jmdh.s266281"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/scs.12637"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/02692163221137105"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hex.12691"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010018\u20102916\u20109"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/jop.2017.021303"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/edbk_243729"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.09.158"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/medethics\u20102018\u2010105226"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzm042"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2016.273"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.156.1.79"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.encep.2007.06.001"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039879"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0013244"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10410236.2017.1331189"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-1005-9_215"},{"key":"e_1_2_10_22_1","first-page":"488","volume-title":"Decision Making: A Psychological Analysis of Conflict, Choice, and Commitment","author":"Janis I. L.","year":"1977"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1188\/10.onf.e124\u2010e132"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12596"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1188\/19.cjon.592\u2010598"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25201"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-79515-3"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-0753-5_2647"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2022.04.012"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/cco.0000000000000951"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2009.10.010"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.70291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:48:53Z","timestamp":1761547733000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.70291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/pon.70291"],"URL":"https:\/\/doi.org\/10.1002\/pon.70291","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70291"}}