{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T18:27:54Z","timestamp":1775845674950,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Informal caregivers of patients with terminal cancer can experience an emotionally difficult time in the final stages of their caregiving journey with implications on their bereavement experience. The current study examined anxiety and depression among caregivers of terminal cancer patients and subsequent bereavement adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Caregivers from the Singapore COMPASS cohort study (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0192)\u00a0were prospectively followed from 6\u2010month pre\u2010 to 6\u2010month post\u2010patient death. Multinomial and logistic regression models were performed to examine factors associated with anxiety, depression and complicated grief that may be targets for intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Rates of anxiety and depression significantly increased closer to patient death (Anxiety: 47%\u201361%; Depression: 31%\u201342%) before decreasing 6\u2010month post\u2010patient death (Anxiety: 21%, Depression: 24%). 16% of caregivers reported persistent anxiety and 15% reported persistent depression from 6\u2010month pre\u2010 to 6\u2010month post\u2010patient death, which were associated with the following pre\u2010death caregiver factors: poorer physical health and high caregiving burden impacting their schedule and health. 33% of caregivers reported sub\u2010threshold\/likely complicated grief, which was associated with close caregiver\u2010patient relationship, caregiver anxiety or depression at pre\u2010patient death and greater perceived patient suffering.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Efforts to identify and support caregivers pre\u2010 and post\u2010patient death are important to mitigate psychological sequalae.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70319","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T01:56:20Z","timestamp":1762480580000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anxiety, Depression and Bereavement Adjustment: A Prospective Study of Informal Caregivers of Terminal Cancer Patients"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1720-4718","authenticated-orcid":false,"given":"Irene","family":"Teo","sequence":"first","affiliation":[{"name":"Department of Psychosocial Oncology National Cancer Centre Singapore  Singapore"},{"name":"Lien Centre for Palliative Care Duke\u2010NUS Medical School  Singapore"},{"name":"Health Services &amp; 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Systems Research Duke\u2010NUS Medical School  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6443-9686","authenticated-orcid":false,"given":"Eric","family":"Finkelstein","sequence":"additional","affiliation":[{"name":"Lien Centre for Palliative Care Duke\u2010NUS Medical School  Singapore"},{"name":"Health Services &amp; Systems Research Duke\u2010NUS Medical School  Singapore"},{"name":"Department of Population Health Sciences Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"COMPASS group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2020.08.028"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28495"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ppo.0b013e3182a5babe"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5630"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951523000111"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022\u20103514.83.5.1150"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2015.07.017"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12904\u2010022\u201001045\u20109"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2021.03.018"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2006.06.012"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61816-9"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12606"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.817936"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2021.06.006"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjc.12344"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5713"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4529"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12904\u2010022\u201001096\u2010y"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2025.102589"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4610"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010clinpsy\u2010081219\u2010093600"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909113514626"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269216315603261"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2025.105909"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2016.09.013"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066066"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12904\u2010021\u201000833\u2010z"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4042"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2021.114240"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjon.2022.100167"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010018\u20104356\u2010z"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100447.1983.tb09716.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1176\/ps.2006.57.9.1291"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.1999.2.185"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19890601)63:11<2321::aid\u2010cncr2820631142>3.0.co;2\u2010t"},{"key":"e_1_2_11_37_1","volume-title":"Measurement of Intergenerational Relations","author":"Mangen D. 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