{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:58:59Z","timestamp":1782287939181,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Three subgroups of adolescent and young adult patients (AYAs; 18\u201339 at diagnosis) with an uncertain or poor cancer prognosis (UPCP\u2014those diagnosed with advanced disease, who will likely die prematurely) were previously identified: those receiving traditional treatments (chemotherapy and\/or radiotherapy), newer treatments (immunotherapy or targeted therapy), and patients with glioma. This study examines differences in health\u2010related quality of life (HRQoL) among these subgroups, and comparisons between AYAs with a UPCP, recently diagnosed AYAs, and a healthy control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data were collected from two AYA cohorts: CORD\u2010AYA (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0155), including AYAs with a UPCP any moment post\u2010diagnosis, and COMPRAYA (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0549), including AYAs within 6\u00a0months after diagnosis. A healthy control group, matched by age and sex, was also included (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0430). All completed the EORTC QLQ\u2010C30.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant HRQoL differences emerged between the traditional versus new treatment group. However, patients with glioma reported significantly lower cognitive functioning compared to patients on newer therapies. AYAs with a UPCP scored lower across all HRQoL scales than the control group. Despite being further along in their disease trajectory, UPCP patients reported HRQoL levels comparable to newly diagnosed patients. AYAs with a UPCP experienced higher financial burden but reported better global quality of life than COMPRAYA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>No significant differences in HRQoL were found between treatment groups, but patients with glioma should be considered a distinct subgroup as they have shown reduced cognitive functioning, necessitating specialized care. Individualized care is crucial, as a lack of personalized support may lead to long\u2010term functional impairment, especially among UPCP patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70337","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T07:57:07Z","timestamp":1763798227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Health\u2010Related Quality of Life in Adolescents and Young Adults With an Uncertain or Poor Cancer Prognosis: Quantitative Baseline Results of the CORD\u2010AYA Study"],"prefix":"10.1002","volume":"34","author":[{"given":"Milou J. P.","family":"Reuvers","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Netherlands Cancer Institute \u2013 Antoni van Leeuwenhoek  Amsterdam the Netherlands"},{"name":"Department of Medical Oncology Erasmus MC Cancer Institute Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle\u2010Brit","family":"Fiebrich\u2010Westra","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Isala Hospital  Zwolle the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan A. F.","family":"Koekkoek","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center  Leiden the Netherlands"},{"name":"Department of Neurology Haaglanden Medical Center  the Hague the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Tromp","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Amsterdam University Medical Center  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans M.","family":"Westgeest","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Amphia Hospital  Breda the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde C. M.","family":"Kouwenhoven","sequence":"additional","affiliation":[{"name":"Department of Neurology Cancer Center Amsterdam Amsterdam University Medical Center Vrije University  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin J.","family":"Beelen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rijnstate Hospital  Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathijs P.","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Northwest Clinics  Alkmaar the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan J.","family":"Verschoor","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Reinier de Graaf Hospital  Delft the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten M. J.","family":"Wijnenga","sequence":"additional","affiliation":[{"name":"Department of Neurology Brain Tumor Center Erasmus MC Cancer Institute Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Netherlands Cancer Institute \u2013 Antoni van Leeuwenhoek  Amsterdam the Netherlands"},{"name":"Division of Tumor Biology and Immunology the Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrianus J.","family":"de Langen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Netherlands Cancer Institute \u2013 Antoni van Leeuwenhoek  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Wilgenhof","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Netherlands Cancer Institute \u2013 Antoni van Leeuwenhoek  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique E. M. M.","family":"Bos","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Erasmus MC Cancer Institute Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne E. J.","family":"Kaal","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7966-5301","authenticated-orcid":false,"given":"Janine","family":"Nuver","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhod\u00e9","family":"Bijlsma","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology UMC Utrecht Cancer Center  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Lalisang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine GROW\u2010School of Oncology and Reproduction Maastricht UMC  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annet W.","family":"Coumou","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Elisabeth\u2010Tweesteden Hospital  Tilburg the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariette J.","family":"Agterof","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology St. Antonius Hospital  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene E. G.","family":"van Hellemond","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Catharina Hospital  Eindhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baukje","family":"Flameling","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology OLVG  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winette T. A.","family":"van der Graaf","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Netherlands Cancer Institute \u2013 Antoni van Leeuwenhoek  Amsterdam the Netherlands"},{"name":"Department of Medical Oncology Erasmus MC Cancer Institute Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Husson","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Netherlands Cancer Institute \u2013 Antoni van Leeuwenhoek  Amsterdam the Netherlands"},{"name":"Departments of Public Health &amp; Surgical Oncology Erasmus MC Cancer Institute Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.6132"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0040"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2021.100096"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ppo.0000000000000343"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.69.7946"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(16)30510\u20101"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2022.05.017"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27486"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2021.100047"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13164045"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.7696"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113421"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nop\/npae080"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010022\u201003207\u2010x"},{"key":"e_1_2_12_16_1","unstructured":"M. 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