{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:42:47Z","timestamp":1784122967291,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenic obesity (SO)\u2212excess adiposity with low muscle strength and mass\u2212is a concern in oncology as it may exacerbate functional decline and cancer\u2010related fatigue (CRF). The European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO) recently proposed diagnostic criteria for SO, but these remain untested in breast cancer (BC). We examined associations between SO, CRF, quality of life (QoL), and physical function in women with early BC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010six patients (48.0\u00a0\u00b1\u00a09.9\u00a0years; stages I\u2013III) underwent assessments of body mass index (BMI) and composition (DXA), waist circumference (WC), and handgrip strength. Physical function was evaluated using the timed up\u2010and\u2010go (TUG) and the 6\u2010m walk test (6\u2010MWT), while QoL and CRF were assessed using the European Organization for Research and Treatment of Cancer\u2013Quality of Life Questionnaire (EORTC QLQ\u2010C30) and the Cancer Fatigue Scale (B\u2010CFS). The ESPEN\u2013EASO consensus was applied to classify participants as Eutrophic (normal BMI and WC), Obesity (high BMI and\/or WC with preserved muscle strength and mass), or SO (high BMI and\/or WC with reduced muscle strength and mass).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Global health\/QoL (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03) was lower in SO (61.6\u00a0\u00b1\u00a07.2) and Obesity (60.4\u00a0\u00b1\u00a03.7) than Eutrophic (81.1\u00a0\u00b1\u00a06.9). Physical functioning scale\/QoL was lower in Obesity (84.6\u00a0\u00b1\u00a02.2) than Eutrophic (97.0\u00a0\u00b1\u00a04.1). Mean physical and overall fatigue in both Obesity (5.3\u00a0\u00b1\u00a05.5 and 19.6\u00a0\u00b1\u00a09.9) and SO (5.0\u00a0\u00b1\u00a04.1 and 18.8\u00a0\u00b1\u00a08.6) were not statistically different from Eutrophic\u00a0(2.0\u00a0\u00b1\u00a02.9 and 14.3\u00a0\u00b1\u00a07.8). TUG was worse in SO (7.5\u00a0\u00b1\u00a00.2\u00a0s) than both Eutrophic (6.6\u00a0\u00b1\u00a00.2\u00a0s) and Obesity (6.8\u00a0\u00b1\u00a00.1\u00a0s\u2212\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). Comparisons were adjusted for age, menopausal status, and physical activity. SO\u2010related traits were correlated to physical function and to domains of QoL and CRF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Obesity and SO are associated with poorer QoL, while SO is also linked with worse physical function in early BC. Assessing SO traits in clinical settings will improve the management of BC, though confirmation across disease stages is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70354","type":"journal-article","created":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T16:18:39Z","timestamp":1765124319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The ESPEN and EASO Criteria for Sarcopenic Obesity in Early Breast Cancer: Association With Physical Function, Fatigue and Quality of Life"],"prefix":"10.1002","volume":"34","author":[{"given":"Priscila de Ata\u00eddes","family":"Ferreira","sequence":"first","affiliation":[{"name":"Department of Nutrition University of Bras\u00edlia  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1240-7743","authenticated-orcid":false,"given":"Tha\u00eds Muniz Montalv\u00e3o","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Nutrition University of Bras\u00edlia  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Leite","family":"Colombelli","sequence":"additional","affiliation":[{"name":"Department of Physical Education University of Bras\u00edlia  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breno Lima","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Physical Education University of Bras\u00edlia  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00eddia Mara Bezerra","family":"de Melo","sequence":"additional","affiliation":[{"name":"Department of Physical Education University of Bras\u00edlia  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1664-1614","authenticated-orcid":false,"given":"Anthony J.","family":"Blazevich","sequence":"additional","affiliation":[{"name":"Centre for Human Performance School of Medical and Health Sciences Edith Cowan University  Joondalup Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo M.","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Nutrition University of Bras\u00edlia  Bras\u00edlia Brazil"},{"name":"Department of Physical Education University of Bras\u00edlia  Bras\u00edlia Brazil"},{"name":"Centre for Human Performance School of Medical and Health Sciences Edith Cowan University  Joondalup Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13050723"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20211033"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21405"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010019\u20100176\u20108"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.5327"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12379"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010019\u201005352\u20103"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.12.003"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.0137"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.ccr\u201016\u20100940"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010020\u20106645\u20106"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012\u20100169"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(08)70153\u20100"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912\u2010016\u20100546\u20105"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.127"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215662"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430\u2010021\u201000931\u20104"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010020\u201005624\u20103"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215292"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12928"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1188\/21.onf.558\u2010576"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000521241"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.12820\/rbafs.v.6n2p5\u201018"},{"key":"e_1_2_10_26_1","first-page":"102","article-title":"Validation of the Portuguese Version of the Subjective Global Assessment Produced by the Patient","author":"Gonzalez M.","year":"2010","journal-title":"Jornal Brasileiro de Nutri\u00e7\u00e3o Cl\u00ednica"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0363\u20105023(84)80146\u2010x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10060510"},{"key":"e_1_2_10_29_1","unstructured":"WHO technical report series; 854.Physical Status: The Use of and Interpretation of Anthropometry Report of a WHO Expert Committee. (1995)."},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2008.10.003"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.1991.tb01616.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/09593985.2019.1570577"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0959\u20108049(01)00448\u20108"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1415\u2010790x2013000200011"},{"key":"e_1_2_10_35_1","volume-title":"EORTC QLQ\u2010C30 Scoring Manual","author":"Fayers P. M.","year":"2001"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2019.03.011"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16372"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00863"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010021\u201006787\u20105"},{"key":"e_1_2_10_40_1","unstructured":"SloanJ. A. LiuH. SateleD. V. et\u00a0al.Prognostic Significance of Baseline Fatigue for Overall Survival: A Patient\u2010Level Meta\u2010Analysis of 43 Oncology Clinical Trials With 3915 Patients. (2019);"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2004.02.060"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010021\u201006171\u20103"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.11673"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2016.10.014"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.2147\/jmdh.s274660"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu010"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010023\u201006935\u2010x"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010019\u20100310\u20107"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223\u2010019\u201000545\u2010w"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.70354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pon.70354","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.70354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T16:49:28Z","timestamp":1776012568000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.70354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/pon.70354"],"URL":"https:\/\/doi.org\/10.1002\/pon.70354","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2024-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70354"}}