{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:25:32Z","timestamp":1772987132565,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The benefits and harms of cancer screening must be balanced for all participant groups, including those who go on to have cancer diagnosed. The psychological impact of having cancer diagnosed through screening, rather than via another route, is currently unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We conducted a systematic review to describe the psychological impact of detecting cancer through screening (screen\u2010detected) compared to other routes (non\u2010screen\u2010detected).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eligible studies investigated the psychological impact of screen\u2010detected cancer. PubMed, Embase, and PsycINFO were searched. Two reviewers independently screened all titles, abstracts and full texts. We assessed quality using the Mixed Methods Appraisal Tool. Psychological outcome data were extracted for groups with screen\u2010detected and non\u2010screen\u2010detected cancers, calculating Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      where relevant. Results were narratively synthesized.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 33 papers presenting quantitative results from 31 studies. All were considered medium to high quality. Studies measured psychological outcomes across six cancer screening programmes (breast, prostate, colorectal, lung, cervical and ovarian) using 31 different outcome measures. Receiving a screen\u2010detected cancer diagnosis seemed to be associated with a small or moderate short\u2010term increase in adverse psychological outcomes. In studies comparing outcomes by detection route, most found no difference (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a016 studies), or that patients with screen\u2010detected cancers fared better than those with non\u2010screen\u2010detected cancers (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a011 studies), but effect sizes were small.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A screen\u2010detected cancer diagnosis can lead to short\u2010term adverse psychological outcomes; however, there is no strong evidence for a difference in psychological outcomes by detection route. Greater consistency of measures and timepoints would facilitate between\u2010study comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration<\/jats:title>\n                    <jats:p>PROSPERO 2017 CRD42017075269.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70358","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T04:15:57Z","timestamp":1769228157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Psychological Impact of Screen\u2010Detected Cancer: A Systematic Review"],"prefix":"10.1002","volume":"35","author":[{"given":"Emma","family":"Lidington","sequence":"first","affiliation":[{"name":"Centre for Cancer Screening, Prevention and Early Diagnosis, Wolfson Institute of Population Health Queen Mary University of London  London UK"},{"name":"School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divyadharshini","family":"Ragupathy","sequence":"additional","affiliation":[{"name":"School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0136-6197","authenticated-orcid":false,"given":"Ninian","family":"Schmeising\u2010Barnes","sequence":"additional","affiliation":[{"name":"Centre for Cancer Screening, Prevention and Early Diagnosis, Wolfson Institute of Population Health Queen Mary University of London  London UK"},{"name":"School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Dibden","sequence":"additional","affiliation":[{"name":"Centre for Cancer Screening, Prevention and Early Diagnosis, Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Waller","sequence":"additional","affiliation":[{"name":"Centre for Cancer Screening, Prevention and Early Diagnosis, Wolfson Institute of Population Health Queen Mary University of London  London UK"},{"name":"School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Marlow","sequence":"additional","affiliation":[{"name":"Centre for Cancer Screening, Prevention and Early Diagnosis, Wolfson Institute of Population Health Queen Mary University of London  London UK"},{"name":"School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l408"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.56.12.899"},{"key":"e_1_2_10_4_1","unstructured":"Cancer Research UK Screening for Cancer https:\/\/www.cancerresearchuk.org\/about\u2010cancer\/spot\u2010cancer\u2010early\/screening."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2018.0481"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15\u20100969"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f5334"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18\u20100694"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.12745"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010021\u201003017\u20107"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckt074"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1369\u20106513.2002.00166.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010022\u201009261\u20105"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102022\u2010061211"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103999(92)90051\u20103"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.705"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102017\u2010017565"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_10_19_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins J. 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