{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:25:23Z","timestamp":1772987123299,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Global analyses of hematologic malignancies often lack subtype integration and advanced forecasting, limiting public health planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using GBD 2021 data (1990\u20132021), we analyzed age\u2010standardized incidence (ASIR), mortality (ASDR), and disability\u2010adjusted life years (DALYs) for leukemia, lymphoma, and multiple myeloma. Spatiotemporal models quantified age\u2010, sex\u2010, and Socio\u2010demographic Index (SDI)\u2010stratified disparities. The Prophet model forecasted trends to 2031.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 2021, global ASIRs were 5.63, 7.93, and 1.74 per 100,000 for leukemia, lymphoma, and multiple myeloma, respectively. ASIR correlated positively with SDI for all subtypes (e.g.,\u00a0multiple myeloma:\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a00.81,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Mortality patterns were heterogeneous; Hodgkin lymphoma ASDR correlated negatively with SDI (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u00a0=\u00a0\u22120.26,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Projections suggest stable or declining ASDRs by 2031 (e.g.,\u00a0leukemia: 3.86 to 3.40) but persistent male predominance. DALYs remain high in low\u2010SDI regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The disparity between high incidence in high\u2010SDI areas and higher mortality fractions in low\u2010SDI areas underscores diagnostic and therapeutic inequities. DALYs reflect associated long\u2010term functional and psychosocial burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study reveals profound global inequalities in hematologic malignancies. Mitigating this burden requires strengthening early diagnosis and treatment in low\u2010SDI regions while integrating psychosocial support into global survivorship care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70365","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:29:21Z","timestamp":1767922161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Global, Regional, and National Burden of Hematologic Malignancies From 1990 to 2021, With Projections of Mortality and Incidence to 2031"],"prefix":"10.1002","volume":"35","author":[{"given":"Yanqi","family":"Kou","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology  Luoyang Henan Province China"},{"name":"Department of Gastroenterology Affiliated Hospital of Guangdong Medical University 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Guangdong Province China"},{"name":"Department of Pathology Guangdong Medical University  Zhanjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yitong","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital of Guangdong Medical University Guangdong Medical University  Zhanjiang City Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoyan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital of Guangdong Medical University Guangdong Medical University  Zhanjiang City Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weimin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital of Guangdong Medical University Guangdong Medical University  Zhanjiang City Guangdong Province 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