{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:53:22Z","timestamp":1779292402935,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cancer pharmacotherapy imposes substantial physical and psychosocial burdens that affect patients' quality of life (QoL). While oncologic outcomes are well studied, the psychological dimensions\u2014particularly future perspective, emotional resilience, and body image\u2014remain underintegrated into routine care. The growing recognition of psycho\u2010oncology highlights the need for synergistic collaboration between oncology and clinical psychology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate changes in QoL before and after pharmacotherapy among women with breast cancer and identify domains most vulnerable to psychological distress, thereby informing the need for integrated psycho\u2010oncologic care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study included 106 women with breast cancer undergoing pharmacotherapy. Sociodemographic and clinical characteristics were collected, including cancer stage, treatment modalities, and baseline cardiometabolic parameters. QoL was assessed pre\u2010 and post\u2010treatment using EORTC QLQ\u2010C30 and BR23 instruments. Paired comparisons were performed using Wilcoxon signed\u2010rank tests, and correlations with age were analyzed using Spearman or Pearson methods as appropriate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Global health status declined significantly after pharmacotherapy (83.3 to 66.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002). Functional domains\u2014including physical, role, and social functioning\u2014also worsened, while emotional functioning improved modestly. Symptom burden increased across fatigue, nausea, pain, appetite loss, and systemic side effects (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Breast\u2010cancer\u2013specific domains such as body image and future perspective showed minimal change but remained highly variable, indicating psychosocial vulnerability. Distress related to hair loss demonstrated a modest inverse correlation with age (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.296;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pharmacotherapy substantially reduces multiple QoL domains, highlighting symptom\u2013function trade\u2010offs and persistent psychological concerns. The patterns in emotional functioning and future perspective indicate unmet psychosocial needs. These findings underscore the imperative for integrated psycho\u2010oncology models to enhance holistic survivorship care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70393","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T16:45:01Z","timestamp":1769273101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Beyond Physical Toxicities: Identifying Psychosocial Domains Requiring Integrated Support in Breast Cancer Pharmacotherapy"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5730-2013","authenticated-orcid":false,"given":"Henry","family":"Sutanto","sequence":"first","affiliation":[{"name":"Internal Medicine Specialist Study Program Department of Internal Medicine Faculty of Medicine Universitas Airlangga  Surabaya Indonesia"},{"name":"Department of Internal Medicine Dr. Soetomo General Academic Hospital  Surabaya Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ami","family":"Ashariati","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Department of Internal Medicine Faculty of Medicine Universitas Airlangga  Surabaya Indonesia"},{"name":"Integrated Oncology Unit Universitas Airlangga Hospital  Surabaya Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2279-0002","authenticated-orcid":false,"given":"Merlyna","family":"Savitri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dr. Soetomo General Academic Hospital  Surabaya Indonesia"},{"name":"Division of Hematology and Medical Oncology Department of Internal Medicine Faculty of Medicine Universitas Airlangga  Surabaya Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Een","family":"Hendarsih","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Department of Internal Medicine Haji General Hospital  Surabaya 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