{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T06:14:13Z","timestamp":1788502453000,"version":"build-2803163510"},"reference-count":92,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As the most prevalent malignancy among women, breast cancer has a potentially shattering impact on quality of life (QoL). However, studies comparing QoL between breast cancer survivors and cancer\u2010free peers have been inconsistent and little is known about possible moderators that contribute to inconsistent findings or specific QoL domains that affect breast cancer survivors most.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This meta\u2010analysis examined QoL differences between breast cancer survivors and controls without breast cancer (\u201ccontrols\u201d hereafter) across multiple QoL instruments and domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched major international and Chinese databases and identified 36 eligible case\u2010control studies comprising 29,433 participants (12,261 survivors, 17,172 controls). Standardized mean differences were calculated using a random\u2010effects model; subgroup analyses and meta\u2010regression examined potential moderators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>QoL impairments varied by assessment instrument. Medical Outcomes Study Short Form surveys showed lower physical component scores in breast cancer survivors (moderate effect size, SMD\u00a0=\u00a0\u22120.52) and small deficits in physical function, emotional role limitations, mental components, and general health domains. The European Organization for Research and Treatment of Cancer questionnaire revealed lower scores in insomnia (SMD\u00a0=\u00a00.80) and financial difficulties (SMD\u00a0=\u00a00.77). Regarding the Functional Assessment of Cancer Therapy\u2010General, breast cancer survivors displayed comparatively large impairments across emotional, functional, and physical well\u2010being domains. Short\u2010term survivors (\u2264\u00a05\u00a0years post\u2010diagnosis) experienced significantly greater deficits than long\u2010term survivors did in physical role limitations and mental health domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Breast cancer survivors experience lower QoL than controls do, particularly in physical and emotional domains. This meta\u2010analysis highlights the importance of developing effective interventions targeting specific QoL domains at different survivorship stages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pon.70398","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T19:39:51Z","timestamp":1771443591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Quality of Life in Breast Cancer Survivors: A Meta\u2010Analysis of Case\u2010Control Studies"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9926-1509","authenticated-orcid":false,"given":"Yi\u2010Ran","family":"Huang","sequence":"first","affiliation":[{"name":"Unit of Psychiatry Department of Public Health and Medicinal Administration Faculty of Health Sciences University of Macau  Macao SAR China"},{"name":"Centre for Cognitive and Brain Sciences University of Macau  Macao SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua\u2010Qing","family":"Xing","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry Department of Public Health and Medicinal Administration Faculty of Health Sciences University of Macau  Macao SAR China"},{"name":"Centre for Cognitive and Brain Sciences University of Macau  Macao SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Ran","family":"Yan","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry Department of Public Health and Medicinal Administration Faculty of Health Sciences University of Macau  Macao SAR China"},{"name":"Centre for Cognitive and Brain Sciences University of Macau  Macao SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Cheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry Department of Public Health and Medicinal Administration Faculty of Health Sciences University of Macau  Macao SAR China"},{"name":"Centre for Cognitive and Brain Sciences University of Macau  Macao SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Feng","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders &amp; National Center for Mental Disorders Beijing Anding Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Smith","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry Department of Public Health and Medicinal Administration Faculty of Health Sciences University of Macau  Macao SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2005-9504","authenticated-orcid":false,"given":"Zhaohui","family":"Su","sequence":"additional","affiliation":[{"name":"School of Public Health Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teris","family":"Cheung","sequence":"additional","affiliation":[{"name":"School of Nursing Hong Kong Polytechnic University  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4821-4764","authenticated-orcid":false,"given":"Gabor S.","family":"Ungvari","sequence":"additional","affiliation":[{"name":"Section of Psychiatry University of Notre Dame Australia  Fremantle Australia"},{"name":"Division of Psychiatry School of Medicine University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Macau  Macao SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3949-1188","authenticated-orcid":false,"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders &amp; 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